Abstract: A method for sharing a geopost includes controlling a shared map image post via a sharing application, capable of sharing a post on a social network, wherein the sharing application comprises a map with a GPS location capable of being authenticated by at least two authentication inputs, providing a prebuilt application protocol which sends the at least two authentication inputs to the third party social network, authorizing a third party social network with a posting permission, where the posting is both shared and sharable, and the sharing application is stored on a non-transitory computer-readable medium, superimposing a semitransparent circle on a map in the user interface, around the GPS location, providing a search input filed and a search function, and providing a hidden posting function capable of publishing to the third party social network only upon touching a portion of the map via the user interface in the mobile software application.

Abstract: Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment of various disorders, such as cancer, autoimmune disorders, and diabetes. Also provided are packaged pharmaceuticals comprising these compositions. The compositions may be administered in combination with another therapeutic agent.

Abstract: Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment of various disorders, such as cancer, autoimmune disorders, and diabetes. Also provided are packaged pharmaceuticals comprising these compositions. The compositions may be administered in combination with another therapeutic agent.

Abstract: Methods for identifying compounds that are inhibitors of the unfolded protein response are provided. In particular, the methods identify compounds that inhibit the activity of IRE1.