Patents by Inventor Douglas E. Koshland

Douglas E. Koshland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for target DNA modification
    Patent number: 9982277
    Abstract: The disclosure provides compositions and methods for increasing efficiency of Cas9-mediated target DNA modification. Specifically, the disclosure provides compositions and methods for carrying out site-directed modification of a target DNA, the methods comprising contacting the target DNA with: a) a complex comprising a Cas9 polypeptide and a guide RNA, and b) a Rad51 polypeptide. The site-directed modification of a target DNA can be carried out in a living cell in vitro, in a living cell in vivo, or in a cell-free system in vitro.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: May 29, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Douglas E. Koshland, Lamia Wahba
  • METHODS AND COMPOSITIONS FOR TARGET DNA MODIFICATION
    Publication number: 20160138045
    Abstract: The disclosure provides compositions and methods for increasing efficiency of Cas9-mediated target DNA modification. Specifically, the disclosure provides compositions and methods for carrying out site-directed modification of a target DNA, the methods comprising contacting the target DNA with: a) a complex comprising a Cas9 polypeptide and a guide RNA, and b) a Rad51 polypeptide. The site-directed modification of a target DNA can be carried out in a living cell in vitro, in a living cell in vivo, or in a cell-free system in vitro.
    Type: Application
    Filed: June 10, 2014
    Publication date: May 19, 2016
    Inventors: Douglas E. Koshland, Lamia Wahba