Abstract: A device for cleaning and defogging an endoscope. A sponge is impregnated with a composition of water, a glycol and a water soluble wetting agent. The impregnated sponge is packaged in a container designed to facilitate cleaning and defogging of the endoscope. In one embodiment, the impregnated sponge is provided in an open container, and the endoscope is wiped against the impregnated sponge. In another embodiment, the impregnated sponge is provided in a tubular container, into which the endoscope is inserted. In yet another embodiment, the impregnated sponge is provided in a device designed to be attached onto an endoscopic trocar cannula. In yet another embodiment, the impregnated sponge is attached to the surface of a flapper valve in an endoscopic trocar cannula, such that the sponge in contacted by the endoscope when the endoscope is inserted in the cannula.