Patents by Inventor Douglas F. Whitman
Douglas F. Whitman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884965Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: GrantFiled: March 31, 2022Date of Patent: January 30, 2024Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Hongwei Zhang
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Publication number: 20220251633Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: ApplicationFiled: March 31, 2022Publication date: August 11, 2022Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Hongwei ZHANG
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Patent number: 11319577Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: GrantFiled: January 23, 2020Date of Patent: May 3, 2022Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Hongwei Zhang
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Patent number: 11001877Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: GrantFiled: February 25, 2019Date of Patent: May 11, 2021Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Charles J. Collins
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Publication number: 20200149093Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: ApplicationFiled: January 23, 2020Publication date: May 14, 2020Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Hongwei ZHANG
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Patent number: 10577647Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: GrantFiled: May 6, 2014Date of Patent: March 3, 2020Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Hongwei Zhang
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Publication number: 20190177779Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: ApplicationFiled: February 25, 2019Publication date: June 13, 2019Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Charles J. COLLINS
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Patent number: 10253354Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: GrantFiled: March 3, 2017Date of Patent: April 9, 2019Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Charles J. Collins
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Publication number: 20180237832Abstract: Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer complementary to a first region of a target nucleic acid and a probe complementary to a second region of the target nucleic acid downstream of the first region under conditions suitable for hybridization of the target nucleic acid with the primer and the probe. The probe in this embodiment comprises a fluorophore and is attached to a solid support. The hybridized probe is cleaved with a nucleic acid polymerase having exonuclease activity to release the reporter from the solid support. The presence of the target nucleic acid is then detected and optionally quantified by detecting a decrease in signal from the reporter on the solid support.Type: ApplicationFiled: April 16, 2018Publication date: August 23, 2018Applicant: LUMINEX CORPORATIONInventors: Brian SCHRADER, Douglas F. WHITMAN
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Patent number: 9970050Abstract: Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer complementary to a first region of a target nucleic acid and a probe complementary to a second region of the target nucleic acid downstream of the first region under conditions suitable for hybridization of the target nucleic acid with the primer and the probe. The probe in this embodiment comprises a fluorophore and is attached to a solid support. The hybridized probe is cleaved with a nucleic acid polymerase having exonuclease activity to release the reporter from the solid support. The presence of the target nucleic acid is then detected and optionally quantified by detecting a decrease in signal from the reporter on the solid support.Type: GrantFiled: January 22, 2015Date of Patent: May 15, 2018Assignee: LUMINEX CORPORATIONInventors: Brian Schrader, Douglas F. Whitman
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Patent number: 9745620Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: GrantFiled: October 16, 2015Date of Patent: August 29, 2017Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Charles J. Collins
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Publication number: 20170175175Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: ApplicationFiled: March 3, 2017Publication date: June 22, 2017Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Charles J. COLLINS
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Patent number: 9587270Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: GrantFiled: June 29, 2010Date of Patent: March 7, 2017Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Hongwei Zhang
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Publication number: 20170044596Abstract: Methods and compositions for assays using catalytic DNA (e.g., that can cleave substrate nucleic acid sequences) are provided.Type: ApplicationFiled: July 18, 2016Publication date: February 16, 2017Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Travis WOHLERS
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Publication number: 20160032373Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: ApplicationFiled: October 16, 2015Publication date: February 4, 2016Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Charles J. COLLINS
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Patent number: 9193991Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: GrantFiled: September 29, 2014Date of Patent: November 24, 2015Assignee: LUMINEX CORPORATIONInventors: Douglas F. Whitman, Charles J. Collins
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Publication number: 20150133338Abstract: Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer complementary to a first region of a target nucleic acid and a probe complementary to a second region of the target nucleic acid downstream of the first region under conditions suitable for hybridization of the target nucleic acid with the primer and the probe. The probe in this embodiment comprises a fluorophore and is attached to a solid support. The hybridized probe is cleaved with a nucleic acid polymerase having exonuclease activity to release the reporter from the solid support. The presence of the target nucleic acid is then detected and optionally quantified by detecting a decrease in signal from the reporter on the solid support.Type: ApplicationFiled: January 22, 2015Publication date: May 14, 2015Inventors: BRIAN SCHRADER, DOUGLAS F. WHITMAN
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Publication number: 20150017646Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: ApplicationFiled: September 29, 2014Publication date: January 15, 2015Inventors: DOUGLAS F. WHITMAN, CHARLES J. COLLINS
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Patent number: 8846317Abstract: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process.Type: GrantFiled: September 18, 2012Date of Patent: September 30, 2014Assignee: Luminex CorporationInventors: Douglas F. Whitman, Charles J. Collins
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Publication number: 20140242586Abstract: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5? of the target-specific primer sequence; a tag sequence 5? of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed. Compositions containing such a nucleic acid molecule and methods of using such a nucleic acid molecule are also disclosed.Type: ApplicationFiled: May 6, 2014Publication date: August 28, 2014Applicant: LUMINEX CORPORATIONInventors: Douglas F. WHITMAN, Hongwei Zhang