Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Abstract: The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities.

Abstract: The laser reference tool of the invention consists of a base that can be releasably mounted to a surface. A housing is mounted on the base such that it can be repositioned relative to the base in a direction parallel to the surface. A turret carrying the laser module is rotatable about first and second orthogonal axes. The laser module is also rotatable relative to the turret about a third axis orthogonal to the first and second axes.

Abstract: The laser reference tool of the invention consists of a base that can be releasably mounted to a surface. A housing is mounted on the base such that it can be repositioned relative to the base in a direction parallel to the surface. A turret carrying the laser module is rotatable about first and second orthogonal axes. The laser module is also rotatable relative to the turret about a third axis orthogonal to the first and second axes.

Abstract: The laser reference tool of the invention consists of a base that can be releasably mounted to a surface. A housing is mounted on the base such that it can be repositioned relative to the base in a direction parallel to the surface. A turret carrying the laser module is rotatable about first and second orthogonal axes. The laser module is also rotatable relative to the turret about a third axis orthogonal to the first and second axes.

Abstract: An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. Also a method for manufacturing the operator includes the steps of passing the worm shaft through the hole with the worm shoulder engaging the internal shoulder and the worm disposed against the first support surface, fitting the arm to the central post, the arm in drivable engagement with the worm, placing the base and the cover together with the worm disposed between the first and second support surfaces and the central post.

Abstract: An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. The operator also includes a cover secured to the base and having a second support surface with a hole therethrough defining an internal shoulder, the second support surface mating with the first support surface. A post extends from the cover and through the aperture in the base when the operator is assembled. An arm is pivotally secured to the post and attachable to the sash to control the movement of the sash between open and closed positions. A worm drivably engages the arm and has a worm shaft and a worm shoulder disposed on the worm shaft.

Abstract: An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. The operator also includes a cover secured to the base and having a second support surface with a hole therethrough defining an internal shoulder, the second support surface mating with the first support surface. A post extends from the cover and through the aperture in the base when the operator is assembled. An arm is pivotally secured to the post and attachable to the sash to control the movement of the sash between open and closed positions. A worm drivably engages the arm and has a worm shaft and a worm shoulder disposed on the worm shaft.

Abstract: A lockable window, and a manual control for a lockable window. The window includes a window sash having a first locking member and a window frame having a second locking member mounted thereon for movement between a locked position cooperating with the first locking member for locking the sash to the frame when closed against the frame and an unlocked position clear of the first locking member to allow movement of the sash relative to the frame. The frame also has an opening therein for allowing access to the second locking member from an interior side of the frame. The lock control has a housing including an enclosure open on one side with a flange around the open one side, the housing being mounted with its enclosure substantially in the frame opening and its flange on the interior side of the frame. A handle is pivotally secured in the housing enclosure and includes an opening at one end.

Abstract: An operator for controlling the movement of a window sash relative to a frame with a raised surface along a frame sill thereof, wherein the operator includes a base having a first support surface, an aperture and a bottom exterior surface with a slot therein, the base attached to the frame with the raised surface fitting substantially within the slot. The operator also includes a cover secured to the base and having a second support surface with a hole therethrough defining an internal shoulder, the second support surface mating with the first support surface. A post extends from the cover and through the aperture in the base when the operator is assembled. An arm is pivotally secured to the post and attachable to the sash to control the movement of the sash between open and closed positions. A worm driveably engages the arm and has a worm shaft and a worm shoulder disposed on the worm shaft.

Abstract: A pharmaceutical composition comprising a solution having an effective amount of famotidine, the solution having a pH in the range of about 4.5 to about 8.0, and a shelf life greater than 30 days.

Abstract: A light-intensity dependent molecular switch comprised of a compound which shuttles an electron or a plurality of electrons from a plurality of electron donors to an electron acceptor upon being stimulated with light of predetermined wavelengths, said donors selected from porphyrins and other compounds, and a method for making said compound.

Abstract: A pharmaceutical composition is provided comprising an unbuffered iso-osmotic aqueous formulation containing an effective amount of ranitidine for the treatment of conditions mediated through histamine H.sub.2 receptors. The formulation has a pH of greater than or equal to 5.0 and less than 6.5 and preferably includes an osmotic adjusting agent chosen from the group consisting of dextrose and sodium chloride.

Abstract: The present invention provides a nutritionally useful highly concentrated amino acid solution. In an embodiment, the formulation has a broad amino acid profile that is both high in branched chain amino acids and high in overall percent of amino acids. Additionally, the present invention provides a method of selecting the amino acid profile so as to obtain a maximum amino acid concentration. To this end, a stable amino acid solution having a nutritionally appropriate balance of amino acids comprising a total amino acid concentration equal to or greater than 18% (wt/vol) is provided. In an embodiment, an amino acid solution is provided comprising approximately 18 to about 22% branched chain amino acids (wt/wt); and a total amino acid concentration equal to or greater than 18% (wt/vol).

Abstract: A pharmaceutical composition is provided comprising an unbuffered iso-osmotic aqueous formulation containing an effective amount of ranitidine for the treatment of conditions mediated through histamine H.sub.2 receptors. The formulation has a pH of greater than or equal to 5.0 and less than 6.5 and preferably includes an osmotic adjusting agent chosen from the group consisting of dextrose and sodium chloride.