Abstract: Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.

Abstract: The disclosure provides Myxoma vims that expresses one or more immunomodulatory transgenes and its use in inhibit-mg and/or treating a hematological cancer in a subject. The disclosure also provides a leukocyte having a Myxoma virus that expresses one or more immunomodulatory transgenes and the use of the leukocyte for inhibiting and/or treating a hematological cancer in a subject.

Abstract: System and methods are provided for warning a worker of a rail vehicle, or an operator of the rail vehicle of the worker. The system includes a worker device, a vehicle device, and a central server. The devices and server operate on one or a combination of actual or simulated satellite navigational signals, and beacon signals to determine the position of the devices, to generate a warning. The position determination may prioritize beacon signals over satellite navigation signals. The position determination may involve correcting a calculated position based on a measured power level of the beacon signal received from the beacon transmitter, an elapsed time since a previous beacon signal was last received by the device from the beacon transmitter, an elapsed time since a previous satellite navigation signal was received by the device, or an accuracy of the position of the device based on the satellite navigation signal.

Abstract: System and methods are provided for warning a worker of a rail vehicle, or an operator of the rail vehicle of the worker. The system includes a worker device, a vehicle device, and a central server. The devices and server operate on one or a combination of actual or simulated satellite navigational signals, and beacon signals to determine the position of the devices, to generate a warning. The position determination may prioritize beacon signals over satellite navigation signals. The position determination may involve correcting a calculated position based on a measured power level of the beacon signal received from the beacon transmitter, an elapsed time since a previous beacon signal was last received by the device from the beacon transmitter, an elapsed time since a previous satellite navigation signal was received by the device, or an accuracy of the position of the device based on the satellite navigation signal.

Abstract: A fence gate assembly comprises an upright having a longitudinal opening and a lateral opening. The assembly also includes an insert received within the longitudinal opening and coupled to the upright. The insert also includes a support portion extending from a rear wall. The assembly further includes a rail at least partially received within a cavity of the insert, the rail including a channel configured to at least partly receive the support portion therein.

Abstract: Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant MYXVs. In some embodiments, the MYXVs are engineered to inactivate or attenuate an activity or expression level of an M153 protein. In some embodiments, the MYXVs are engineered to express one or more transgenes such as a tumor necrosis factor (TNF), interleukin-12 (IL-12), or decorin. Also disclosed herein, in certain embodiments, are methods of using the MYXVs. Some embodiments include providing a MYXV as described herein to a subject in need thereof.

Abstract: Systems and methods for automated calendar coordination based on predictive modeling are described. The systems and methods may provide for receiving availability information for a plurality of attendees, generating a plurality of candidate time periods based on the availability information, ranking the plurality of candidate time periods using a predictive model, selecting a preferred time period based on the ranking of the plurality of candidate time periods, and generating a calendar event based on the preferred time period.

Abstract: A racked fence gate assembly comprises an upright having a longitudinal opening and a lateral opening. The assembly also includes an insert received within the longitudinal opening and coupled to the upright. The insert also includes a support portion extending from a rear wall. The assembly further includes a rail having trimmable areas at proximal and distal ends that is at least partially received within a cavity of the insert at a racking angle, the rail including a channel configured to at least partly receive the support portion therein.

Abstract: A technique facilitates obtaining samples of well fluid or other fluid. A sampling tool comprises a sample chamber for collecting the fluid sample. Access to the sample chamber is controlled with a rod shiftable within the sampling tool. Additionally, a locking mechanism works in cooperation with the rod to lock the rod against undesirable movement at various stages of the sampling operation. The locking mechanism may comprise a pair of locking features which engage a groove in the rod to initially block inadvertent closure of access to the sample chamber and subsequently to block inadvertent opening of access to the sample chamber after collection of the fluid sample.

Abstract: A fence gate assembly comprises an upright having a longitudinal opening and a lateral opening. The assembly also includes an insert received within the longitudinal opening and coupled to the upright. The insert also includes a support portion extending from a rear wall. The assembly further includes a rail at least partially received within a cavity of the insert, the rail including a channel configured to at least partly receive the support portion therein.

Abstract: A patient support system includes a support beam that may translocate along an axial axis of a medical imaging system. At least a portion of the support beam may be disposed within a central bore of the medical imaging system. The patient support system also includes a patient support removably coupled to the support beam and including a backing that may support a patient during an imaging procedure and a restraint extending a longitudinal length of the backing. The restraint includes a first end coupled to the backing and a second end that may be removably coupled to the support beam, and the restraint may secure the patient support to the support beam and to restrain the patient within the patient support.

Abstract: A sampling tool includes a tubular member and a sampling piston positioned within the tubular member. The sampling piston has a bore formed axially-therethrough. A secondary piston is positioned within the bore of the sampling piston. A check valve assembly is positioned at least partially within the tubular member. The secondary piston and the check valve assembly move together with respect to the tubular member.

Abstract: A fence gate assembly comprises an upright having a longitudinal opening and a lateral opening. The assembly also includes an insert received within the longitudinal opening and coupled to the upright. The insert also includes a support portion extending from a rear wall. The assembly further includes a rail at least partially received within a cavity of the insert, the rail including a channel configured to at least partly receive the support portion therein.

Abstract: The invention provides (meth)acrylic oligomers prepared from C1-C20 alkyl and C5-C20 cycloalkyl (meth)acrylates, wherein said oligomers have a Mn of about 300 g/mole to about 3,000 g/mole; a Mw of about 700 g/mole to about 6,000 g/mole; a Mz of about 900 g/mole to about 10,000 g/mole. The oligomers may have a Yellowness Index, according to ASTM E313 of less than 2. The oligomers of the invention are useful as tackifiers in adhesive compositions, but also are believed to be useful also in general polymer modification as plasticizers, leveling agents, viscosity reducers (i.e., rheology modifiers), and for increasing solids content in solvent-borne applications of all types with little detrimental impact on viscosity. The invention also provides adhesive compositions and laminate articles coated on at least one side with the adhesive compositions of the invention.

Abstract: The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.

Abstract: A patient support system includes a support beam that may translocate along an axial axis of a medical imaging system. At least a portion of the support beam may be disposed within a central bore of the medical imaging system. The patient support system also includes a patient support removably coupled to the support beam and including a backing that may support a patient during an imaging procedure and a restraint extending a longitudinal length of the backing. The restraint includes a first end coupled to the backing and a second end that may be removably coupled to the support beam, and the restraint may secure the patient support to the support beam and to restrain the patient within the patient support.

Abstract: A fence gate assembly comprises an upright having a longitudinal opening and a lateral opening. The assembly also includes an insert received within the longitudinal opening and coupled to the upright. The insert also includes a support portion extending from a rear wall. The assembly further includes a rail at least partially received within a cavity of the insert, the rail including a channel configured to at least partly receive the support portion therein.

Abstract: A sampling tool includes a tubular member and a sampling piston positioned within the tubular member. The sampling piston has a bore formed axially-therethrough. A secondary piston is positioned within the bore of the sampling piston. A check valve assembly is positioned at least partially within the tubular member. The secondary piston and the check valve assembly move together with respect to the tubular member.

Abstract: A paddling action simulating exerciser in the form of a kayaking trainer that includes pole, a cord that extends along the pole and linearly displaceably passes therethrough, a hollow spacer that extends between a seating facility and an anchoring layout including a cord guiding layout via which the free ends of the cord are secured to a spring. A multi-directionally adjustable footplate facility that includes an upright foot abutment plate fitted with a heel rest and a toe strap is fitted along the spacer. The spacer, seating facility, leg, footplate facility and guiding layout in constituting a trainer core assembly are laterally rockable by way of rocking formations fitting along slots.

Abstract: A technique facilitates obtaining samples of well fluid or other fluid. A sampling tool comprises a sample chamber for collecting the fluid sample. Access to the sample chamber is controlled with a rod shiftable within the sampling tool. Additionally, a locking mechanism works in cooperation with the rod to lock the rod against undesirable movement at various stages of the sampling operation. The locking mechanism may comprise a pair of locking features which engage a groove in the rod to initially block inadvertent closure of access to the sample chamber and subsequently to block inadvertent opening of access to the sample chamber after collection of the fluid sample.