Abstract: At least one chemical entity chosen from compounds of Formula 2 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical compositions comprising at least one chemical entity of the invention, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.

Abstract: A method for designing an absorbent article. The steps of the method are generating a physical spatial map of saturation of a fluid within an absorbent in a physical test environment, generating a virtual spatial map of saturation of a fluid within an absorbent in a virtual test environment, identifying absorbent-fluid interaction properties for the absorbent such that the virtual spatial map of saturation approximates the physical spatial map of saturation, inputting the absorbent-fluid interaction properties into a virtual model of the absorbent article to produce a representation of at least one feature of the absorbent article, evaluating the virtual model of the absorbent article to determine the performance of the at least one feature of the absorbent article, modifying the design of the absorbent article in response to the performance of the at least one feature of the absorbent article determined from the virtual model of the absorbent article.

Abstract: A method for determining absorbent article effectiveness of a virtual absorbent article. The steps of the method include providing a virtual body model, providing a virtual absorbent article model, providing virtual simulation software, running a virtual simulation of deformation of the virtual absorbent article model in proximity with the virtual body model, running a virtual simulation of the fluid balance of the virtual absorbent article model in proximity with the virtual body model, coupling the virtual simulation of deformation of the virtual absorbent article model and the virtual simulation of the fluid balance of the virtual absorbent article model, and determining absorbent article effectiveness of the virtual absorbent article model in proximity with the virtual body model.

Abstract: A method for designing an absorbent article. The steps of the method are generating a physical spatial map of saturation of a fluid within an absorbent in a physical test environment, generating a virtual spatial map of saturation of a fluid within an absorbent in a virtual test environment, identifying absorbent-fluid interaction properties for the absorbent such that the virtual spatial map of saturation approximates the physical spatial map of saturation, inputting the absorbent-fluid interaction properties into a virtual model of the absorbent article to produce a representation of at least one feature of the absorbent article, evaluating the virtual model of the absorbent article to determine the performance of the at least one feature of the absorbent article, modifying the design of the absorbent article in response to the performance of the at least one feature of the absorbent article determined from the virtual model of the absorbent article.

Abstract: A method for measuring the partially saturated fluid transport properties of an absorbent. The steps of the method are generating a physical spatial map of saturation of a fluid within an absorbent in a physical test environment, generating a virtual spatial map of saturation of a fluid within an absorbent in a virtual test environment, and identifying the absorbent-fluid interaction properties for the absorbent such that the virtual spatial map of saturation approximates the physical spatial map of saturation.

Abstract: A fuel system includes a fuel tank filler neck, a filler neck closure, and a filler neck closure location monitor associated with the fuel tank filler neck and the filler neck closure.

Abstract: A filler neck cap includes a vacuum-relief valve member that moves from a normally closed position to an opened position when exposed to certain vacuum conditions to open a vent aperture and allow atmosphere to flow therethrough. The filler neck cap also includes a pressure-relief valve member formed to include the vent aperture that is closed normally by the vacuum-relief valve member.

Abstract: Solar energy is collected by collector means supported in space by geostationary satellite and directed to an air buoyant intermediate platform at a position within the upper atmosphere. The laser energy is there converted to microwave energy and beamed down to earth.