Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: A composition containing levosimendan, one or more solubilizing and/or stabilizing agents, and one or more additional pharmaceutically acceptable additives. The one or more solubilizing and/or stabilizing agents may be a cyclodextrin or a cyclodextrin derivative. The cyclodextrin derivative may be a derivative of an alpha-cyclodextrin, or beta-cyclodextrin, or a gamma-cyclodextrin. The cyclodextrin derivative may contain a butyl ether spacer group, an alkyl ether space group, or both. The one or more additional pharmaceutically acceptable additives may be a non-citrate buffer. The composition may be used in a method of treating a health condition, such as heart failure, pulmonary hypertension, chronic kidney disease, amyotrophic lateral sclerosis, stroke, in advance of a planned cardiac surgery, or other health conditions for which a minimally invasive or repeated administration of levosimendan may be beneficial. The composition may be administered subcutaneously.

Abstract: A composition containing levosimendan, one or more solubilizing and/or stabilizing agents, and one or more additional pharmaceutically acceptable additives. The one or more solubilizing and/or stabilizing agents may be a cyclodextrin or a cyclodextrin derivative. The cyclodextrin derivative may be a derivative of an alpha-cyclodextrin, or beta-cyclodextrin, or a gamma-cyclodextrin. The cyclodextrin derivative may contain a butyl ether spacer group, an alkyl ether space group, or both. The one or more additional pharmaceutically acceptable additives may be a non-citrate buffer. The composition may be used in a method of treating a health condition, such as heart failure, pulmonary hypertension, chronic kidney disease, amyotrophic lateral sclerosis, stroke, in advance of a planned cardiac surgery, or other health conditions for which a minimally invasive or repeated administration of levosimendan may be beneficial. The composition may be administered subcutaneously.

Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.

Abstract: A composition containing levosimendan, one or more solubilizing and/or stabilizing agents, and one or more additional pharmaceutically acceptable additives. The one or more solubilizing and/or stabilizing agents may be a cyclodextrin or a cyclodextrin derivative. The cyclodextrin derivative may be a derivative of an alpha-cyclodextrin, or beta-cyclodextrin, or a gamma-cyclodextrin. The cyclodextrin derivative may contain a butyl ether spacer group, an alkyl ether space group, or both. The one or more additional pharmaceutically acceptable additives may be a non-citrate buffer. The composition may be used in a method of treating a health condition, such as heart failure, pulmonary hypertension, chronic kidney disease, amyotrophic lateral sclerosis, stroke, in advance of a planned cardiac surgery, or other health conditions for which a minimally invasive or repeated administration of levosimendan may be beneficial. The composition may be administered subcutaneously.

Abstract: Methods of (i) reducing morbidity and/or mortality in a human patient undergoing cardiac surgery; (ii) preventing, or reducing the risk of development of, LCOS in a human patient undergoing cardiac surgery; or (iii) reducing the risk of, intensity of, or occurrence of, one or more postoperative adverse events in a human patient undergoing cardiac surgery. The methods can involve (a) a first period of administering to the patient levosimendan for about 1 hour, in which the administration of levosimendan during the first period is initiated: (i) before skin incision for the cardiac surgery, and (ii) at an infusion dose of about 0.2 ?g/kg/min; and (b) a second period of administering to the patient levosimendan for about 23 hours, in which the administration of levosimendan during the second period is initiated at an infusion dose of about 0.1 ?g/kg/min.

Abstract: A computing device (e.g., a processor executing instructions on the computing device) receives an input (e.g., from a user or from a data stream) into a cell of a table (e.g., a cell of a spreadsheet, worksheet, or workbook). If the input is a sum (e.g., a formula whose result is the sum of previous cells), then the computing device renders a total column representing the sum on a waterfall chart (e.g., on a user interface rendered on an electronic display). Otherwise, if the input is a static value (e.g., an integer or decimal number), then the computing device renders a change column representing the static value.

Abstract: A propulsion arrangement for a marine vessel is disclosed. The propulsion arrangement comprises an engine (12, 14) for propelling the vessel and an electrical machine (26, 28) coupled to the engine. The electrical machine is arranged to supply onboard electrical power for the vessel. A control unit (44) controls the electrical machine such that the electrical machine is selectively operable as a generator or a motor. The control unit and the electrical machine are arranged such that the electrical machine when operating as a motor can supplement the power of the engine while the engine is in operation. In one embodiment, the control unit and the electrical machine are arranged to provide active damping of the engine torque.

Abstract: A propulsion arrangement for a marine vessel is disclosed. The propulsion arrangement comprises an engine (12, 14) for propelling the vessel and an electrical machine (26, 28) coupled to the engine. The electrical machine is arranged to supply onboard electrical power for the vessel. A control unit (44) controls the electrical machine such that the electrical machine is selectively operable as a generator or a motor. The control unit and the electrical machine are arranged such that the electrical machine when operating as a motor can supplement the power of the engine while the engine is in operation. In one embodiment, the control unit and the electrical machine are arranged to provide active damping of the engine torque.

Abstract: A system and method for safely slowing or stopping a vehicle by selectively replacing a genuine engine control signal with a spoofed engine control signal to slow or stop a vehicle in a gradual or stepped manor. The operator is allowed control of the vehicle (e.g. genuine engine control signal) if the speed is below a threshold speed and the operator is denied control of the vehicle (e.g. spoofed engine control signal) if the speed is above the threshold speed, thus forcing the vehicle to slow to the threshold speed. The threshold is gradually reduced over time, causing the operator to stop the vehicle.

Abstract: A method, apparatus, and computer usable code to grant access to a scripted code hosted at a host site wherein the host site has a window read-only property. A computer client receives a key-code. The computer client determines if key-code matches a known correct window-returning code. Based on that, the computer invokes the key-code to obtain a read-only property of the key-code and determines if the read-only property matches the known correct window read-only property. Invoking means treating the key-code as a computer instruction and executing the computer instruction. The computer may grant access based on a determination that the read-only property matches.

Abstract: A method, data processing system, and computer usable code are provided for generating content dynamically without a Web server. Responsive to a request to display a document containing markup language content on a client data processing system, a determination is made as to whether a utility script is present in the document. A utility application associated with the utility script is loaded on the client data processing system, if the utility script is present. Then, the utility application processes the utility script to dynamically generate dynamic content for display with markup language content.

Abstract: A method, system and apparatus for browser based enablement through customized temporary browser profiles. A method for enabling a browser based application through a customized temporary browser profile can include the following steps. First, responsive to a request to provide a browser based application to a content browser in a client computing device, a customized browser profile can be applied in lieu a default browser profile in the content browser. Subsequently, the browser based application can be loaded in the content browser and the customized browser profile can be deleted in temporal proximity to the loading step. Preferably, the applying step can include receiving wrapper logic in the content browser; and, executing the wrapper logic to configure the customized browser profile and to apply the customized browser profile to the content browser.

Abstract: A system and method for retrieving class package name from a class file if not known or found by the Java class loader of the Java virtual machine at load time. An algorithm is derived which uses the class file to obtain the class package name by iterating the directory names of the class file in the user's current operating system. An output is provided to the user when the class package name is found and it is loaded by the Java class loader; when an error occurs after which the error message indicates that the prerequisite class of the class file is missing; or when the class package name itself is invalid.

Abstract: A building cluster is provided with each building consisting of a stressed skin floor unit, stressed skin roof units and wall panels separating the two, at least some of the wall panels being connected to the roof and floor units by shear resisting brackets. A waterproof covering is provided for each building and the buildings have sufficient excess strength so that wall panels may be removed to allow a great degree of choice in the number and disposition of wall panels which maximize user choice in the disposition of doors and openings from one building into another in the cluster.

Abstract: A structural building panel in which there is a core consisting of two sets of strips which cross each other and a pair of skins on either side of the core, with the scale of the cells being between a minimum of 12 inches square with 3/8 inch webs and a maximum of a depth of 12 inches before buckling occurs in the webs so that for a skin thickness of 3/8 inch, a cell width of 21 inches is possible before buckling occurs in the skin, the webs and skins being selected from plywood, veneer board, particle board and fiber reinforced cementitious materials. The webs are preferably bonded one to the other at junctions thereof. The panels are preferably joined to each other by trapezoidal grooves in which a shaped member is fixed.