Abstract: In one embodiment, a case transfer apparatus includes a base, a feeding device having a first end tapering to a second end that is coupled to the base, a motor disposed on the base, a rotatable feed wheel assembly disposed on the base and coupled to the motor, the rotatable feed wheel assembly adapted to receive at least one case via gravitational force from a feeding device, and a roller plate coupled to the motor and disposed adjacent the rotatable feed wheel assembly within a case receiving region where the at least one case is rotated and heated.

Abstract: A method and apparatus for sizing ammunition cartridge cases includes a cartridge case trimmer including a cylindrical housing, a mandrel detachably coupled to a longitudinally-oriented opening formed in a first side of the cylindrical housing, the mandrel having a first end including a cutting tool disposed in a slot on the first end and comprising one or more notched cutting surfaces, the mandrel having a second end opposing the first end, the second end protruding from the first side of the cylindrical housing and sized to be received in a chuck, a bearing disposed within the cylindrical housing adjacent to a second side of the cylindrical housing, and an insert comprising a tapered region disposed in an inside diameter of an inner ring of the bearing.

Abstract: A method and apparatus for sizing ammunition cartridge cases includes a cartridge case trimmer including a cylindrical housing, a mandrel detachably coupled to a longitudinally-oriented opening formed in a first side of the cylindrical housing, the mandrel having a first end including a cutting tool disposed in a slot on the first end and comprising one or more notched cutting surfaces, the mandrel having a second end opposing the first end, the second end protruding from the first side of the cylindrical housing and sized to be received in a chuck, a bearing disposed within the cylindrical housing adjacent to a second side of the cylindrical housing, and an insert comprising a tapered region disposed in an inside diameter of an inner ring of the bearing.

Abstract: A method and apparatus for sizing ammunition cartridge cases includes a cartridge case trimmer including a cylindrical housing, a mandrel detachably coupled to a longitudinally-oriented opening formed in a first side of the cylindrical housing, the mandrel having a first end including a cutting tool disposed in a slot on the first end and comprising one or more notched cutting surfaces, the mandrel having a second end opposing the first end, the second end protruding from the first side of the cylindrical housing and sized to be received in a chuck, a bearing disposed within the cylindrical housing adjacent to a second side of the cylindrical housing, and an insert comprising a tapered region disposed in an inside diameter of an inner ring of the bearing.

Abstract: A method and apparatus for sizing ammunition cartridge cases includes a cartridge case trimmer including a cylindrical housing, a mandrel detachably coupled to a longitudinally-oriented opening formed in a first side of the cylindrical housing, the mandrel having a first end including a cutting tool disposed in a slot on the first end and comprising one or more notched cutting surfaces, the mandrel having a second end opposing the first end, the second end protruding from the first side of the cylindrical housing and sized to be received in a chuck, a bearing disposed within the cylindrical housing adjacent to a second side of the cylindrical housing, and an insert comprising a tapered region disposed in an inside diameter of an inner ring of the bearing.

Abstract: In one embodiment, a case transfer apparatus includes a base, a feeding device having a first end tapering to a second end that is coupled to the base, a motor disposed on the base, a rotatable feed wheel assembly disposed on the base and coupled to the motor, the rotatable feed wheel assembly adapted to receive at least one case via gravitational force from a feeding device, and a roller plate coupled to the motor and disposed adjacent the rotatable feed wheel assembly within a case receiving region where the at least one case is rotated and heated.

Abstract: A method and apparatus for annealing cylindrical cases for ammunition cartridges or other tubular casings is provided. In one embodiment, a case annealing apparatus is provided. The case annealing apparatus includes a base, a feeding device having a first end tapering to a second end that is coupled to the base, a rotatable feed wheel assembly disposed adjacent a second end of the feeding device, a linear slide mechanism disposed adjacent the rotatable feed wheel assembly defining a portion of a case receiving region, and a heating device disposed adjacent the case receiving region, the heating device operable to heat a portion of a case retained in the case receiving region.

Abstract: A method and apparatus for annealing cylindrical cases for ammunition cartridges or other tubular casings is provided. In one embodiment, a case annealing apparatus is provided. The case annealing apparatus includes a base, a feeding device having a first end tapering to a second end that is coupled to the base, a rotatable feed wheel assembly disposed adjacent a second end of the feeding device, a linear slide mechanism disposed adjacent the rotatable feed wheel assembly defining a portion of a case receiving region, and a heating device disposed adjacent the case receiving region, the heating device operable to heat a portion of a case retained in the case receiving region.

Abstract: The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

Abstract: The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.

Abstract: The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signaling (SOCS) interaction in controlling cytokine signaling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signaling. Control of cytokine signaling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

Abstract: The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.

Abstract: The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associate therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signaling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.

Abstract: The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

Abstract: The present invention relates generally to antibodies that bind to the Interleukin-13 receptor ?1 chain (IL-13R?1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R?1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R?1/ligand interaction is also provided.

Abstract: The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.

Abstract: The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.