Abstract: An automatic personalized response generation system and process receives user email containing questions and knowledge base articles through an email receiver integrated to an email engine and stores the user emails in a knowledge database. A gatekeeper module classifies incoming emails using structured criteria. A knowledge module gathers and organizes relevant information from the knowledge database and the gatekeeper module. An orchestrator module then routes the classified emails and relevant information to either a responder module or a human agent. The responder module crafts personalized responses, which are then refined by a modify module according to specific quality criteria. Throughout the personalized response generation process, the gatekeeper module, the knowledge module, the orchestrator module, the responder module, and the modify module utilize specialized prompts to guide an Artificial Intelligence (AI) engine via a prompt generator in performing its designated tasks.