Patents by Inventor Douglas Hurd
Douglas Hurd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11910932Abstract: A motion seat is described that includes a chassis, a seat frame, a seat cushion, a backrest, and a resilient hinge. The seat frame is attached to the chassis and the seat cushion and the backrest are each attached to the seat frame. The resilient hinge formed as a unitary body and may be formed from a resilient polymer. The seat cushion and/or the backrest is pivotably attached to the seat frame with the resilient hinge.Type: GrantFiled: February 13, 2023Date of Patent: February 27, 2024Assignee: American Leather Operations, LLCInventors: Jeff Weber, Anders Larsen, Douglas L. Gasal, Jared Hurd, Robert B. Duncan, Kevin Nguyen
-
Patent number: 10198553Abstract: The invention combines the fields of comparative genomic hybridization (CGH) analysis and SNP array analysis. It relates to methods for detecting and mapping genetic abnormalities associated with various diseases. In particular the invention provides a method for simultaneously performing array CGH and SNP array analysis on a genomic DNA sample comprising contacting a nucleic acid array which comprises a first probe set and a second probe set with a genomic DNA sample, comprising a test and reference sample, under hybridization conditions, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the first probe set, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the second probe set; and using the data obtained to determine the copy number of at least one locus; and at least one SNP in the genomic DNA sample.Type: GrantFiled: January 23, 2017Date of Patent: February 5, 2019Assignee: OXFORD GENE TECHNOLOGY (OPERATIONS) LTD.Inventors: Douglas Hurd, Edwin Southern
-
Publication number: 20170226501Abstract: The invention relates to the rapid enrichment of nucleic acid molecules of interest from complex mixtures of nucleic acids for the purpose of sequencing genes and variants, e.g. for clinical uses as well as other applications. A hybridisation column comprising an inner channel, wherein a portion of said channel is filled completely with a porous solid support comprising (a) a plurality of interconnected, micron-sized voids that permit a fluid to flow between them and the remainder of the channel, and (b) a plurality of hybridisation probes, which are bound to the surfaces of the solid support forming the voids is disclosed.Type: ApplicationFiled: August 14, 2015Publication date: August 10, 2017Applicant: OXFORD GENE TECHNOLOGY (OPERATIONS) LTD.Inventors: Oliver MILLER, Graham SPEIGHT, Ed SOUTHERN, Mike MCANDREW, Douglas HURD
-
Publication number: 20170154152Abstract: The invention combines the fields of comparative genomic hybridisation (CGH) analysis and SNP array analysis. It relates to methods for detecting and mapping genetic abnormalities associated with various diseases. In particular the invention provides a method for simultaneously performing array CGH and SNP array analysis on a genomic DNA sample comprising contacting a nucleic acid array which comprises a first probe set and a second probe set with a genomic DNA sample, comprising a test and reference sample, under hybridisation conditions, comparing the amount of test sample and reference sample hybridised to the hybridisation probes of the first probe set, comparing the amount of test sample and reference sample hybridised to the hybridisation probes of the second probe set; and using the data obtained to determine the copy number of at least one locus; and at least one SNP in the genomic DNA sample.Type: ApplicationFiled: January 23, 2017Publication date: June 1, 2017Inventors: Douglas HURD, Edwin SOUTHERN
-
Patent number: 9587278Abstract: The invention combines the fields of comparative genomic hybridization (CGH) analysis and SNP array analysis. It relates to methods for detecting and mapping genetic abnormalities associated with various diseases. In particular the invention provides a method for simultaneously performing array CGH and SNP array analysis on a genomic DNA sample comprising contacting a nucleic acid array which comprises a first probe set and a second probe set with a genomic DNA sample, comprising a test and reference sample, under hybridization conditions, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the first probe set, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the second probe set; and using the data obtained to determine the copy number of at least one locus; and at least one SNP in the genomic DNA sample.Type: GrantFiled: January 7, 2011Date of Patent: March 7, 2017Assignee: OXFORD GENE TECHNOLOGY (OPERATIONS) LTD.Inventors: Douglas Hurd, Edwin Southern
-
Publication number: 20170016047Abstract: A method of enriching a sample of circulating cell-free DNA for DNA derived from a foetus or from a tumour includes carrying out amplification of DNA such that amplification of longer DNA molecules is discriminated against. This results in preferential amplification of foetal or tumour DNA, which can then be analysed using, for example, array comparative genome hybridisation.Type: ApplicationFiled: March 9, 2015Publication date: January 19, 2017Inventors: Edwin Southern, Douglas Hurd, Dietrich Lueerssen, James Reid, Lyn Chitty
-
Publication number: 20170016054Abstract: A method of detecting copy number variations in foetal or tumour DNA within a sample of circulating cell-free DNA includes carrying out amplification of DNA such that amplification of longer DNA molecules is discriminated against. This results in preferential amplification of foetal or tumour DNA, which can then be analysed using, for example,array comparative genome hybridisation.Type: ApplicationFiled: March 9, 2015Publication date: January 19, 2017Inventors: Edwin Southern, Douglas Hurd, Dietrich Lueerssen, James Reid, Lyn Chitty
-
Publication number: 20130102476Abstract: The invention combines the fields of comparative genomic hybridisation (CGH) analysis and SNP array analysis. It relates to methods for detecting and mapping genetic abnormalities associated with various diseases. In particular the invention provides a method for simultaneously performing array CGH and SNP array analysis on a genomic DNA sample comprising contacting a nucleic acid array which comprises a first probe set and a second probe set with a genomic DNA sample, comprising a test and reference sample, under hybridisation conditions, comparing the amount of test sample and reference sample hybridised to the hybridisation probes of the first probe set, comparing the amount of test sample and reference sample hybridised to the hybridisation probes of the second probe set; and using the data obtained to determine the copy number of at least one locus; and at least one SNP in the genomic DNA sample.Type: ApplicationFiled: January 7, 2011Publication date: April 25, 2013Inventors: Douglas Hurd, Edwin Southern, Richard Stark
-
Patent number: 6074829Abstract: A method for detecting an interaction between two proteins while eliminating false positive interactions, the method being particularly useful for application in the two-hybrid system and for the screening of libraries of unknown proteins. In a two-hybrid system employing the method, two different repoter genes having different promoters and two different DNA-binding domains which specifically bind to those promoters, are used.Type: GrantFiled: August 25, 1998Date of Patent: June 13, 2000Assignee: Amersham International PLCInventors: Douglas Hurd, Rachel Alison Fallon, Michael White, Nicholas Jones
-
Patent number: 5948620Abstract: The invention relates to modified two-hybrid systems, in particular a reverse two-hybrid system which employs as a reporter a gene encoding a modifying agent such as an enzyme, and a signal agent which is modified by the enzyme usually by being broken down, such that in the event of an inhibition of binding of the two hybrid proteins a detectable signal is produced. The system is particularly useful for drug screening.Type: GrantFiled: August 4, 1997Date of Patent: September 7, 1999Assignee: Amersham International PLCInventors: Douglas Hurd, Rachel Alison Fallon, Nicholas Ian Workman, Susan Jane Dale
-
Patent number: 5932441Abstract: DNA constructs and vectors are provided for differential expression of proteins in different expression systems, to enable expression of a protein of interest alone or as part of a fusion protein without the need to transfer the coding sequence for the protein of interest from one vector to another.Type: GrantFiled: January 20, 1998Date of Patent: August 3, 1999Assignee: Amersham International PLCInventors: Colin Ronald Goding, Michael White, Bahriye Ugur Yavuzer, Douglas Hurd