Patents by Inventor Douglas Joseph Dobrozsi
Douglas Joseph Dobrozsi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11384357Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more fungi species from the genus Malassezia.Type: GrantFiled: February 8, 2019Date of Patent: July 12, 2022Assignee: The Procter and Gamble CompanyInventors: Juan Esteban Velasquez, Amy Violet Trejo, Laurie Ellen Breyfogle, James Patrick Henry, Douglas Joseph Dobrozsi, Gregory Allen Penner
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Publication number: 20200002703Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more fungi species from the genus Malassezia.Type: ApplicationFiled: February 8, 2019Publication date: January 2, 2020Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Laurie Ellen Breyfogle, James Patrick Henry, Douglas Joseph Dobrozsi, Gregory Allen Penner
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Publication number: 20180078642Abstract: Edible compositions are provided and comprise a soluble mineral component and/or a phosphate component in amounts effective for use as an oral medicament. The soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof. The edible compositions are advantageously companion animal chews, treats or supplements. Further disclosed are methods of making the chews, treats or supplements as are methods of treating conditions of the oral cavity.Type: ApplicationFiled: November 27, 2017Publication date: March 22, 2018Applicant: Mars, IncorporatedInventors: Edward Russell Cox, Douglas Joseph Dobrozsi, Thomas Edward Huetter, Allan John Lepine, Susan Ruth Ward
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Patent number: 9827314Abstract: Disclosed herein are a variety of embodiments of compositions and methods which are each adapted for use by a companion animal. In one embodiment, an edible composition comprising an amount of a soluble mineral component is disclosed, wherein the soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof, wherein the amount is an effective amount for use as an oral medicament. In further embodiments, a phosphate component is included. The edible compositions are advantageously companion animal foods or supplements. Further disclosed are methods selected from treating oral cavity tartar, oral cavity plaque, periodontal disease, gingivitis, breath odor and combinations thereof comprising orally administering a described composition to a companion animal.Type: GrantFiled: December 8, 2003Date of Patent: November 28, 2017Assignee: Mars, IncorporatedInventors: Edward Russell Cox, Douglas Joseph Dobrozsi, Thomas Edward Huetter, Allan John Lepine, Susan Ruth Ward
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Patent number: 7138133Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.Type: GrantFiled: October 10, 2001Date of Patent: November 21, 2006Assignee: The Procter & Gamble CompanyInventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Francis Joseph David Bealin-Kelly, Jayant Eknath Khanolkar, Benoit Maurice Mullet, Shane Michael DE LA Harpe, Brian James Robbins
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Patent number: 6846495Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: GrantFiled: December 20, 1999Date of Patent: January 25, 2005Assignee: The Procter & Gamble CompanyInventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Kishor Jivanlal Desai, Brian James Robbins
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Patent number: 6638521Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.Type: GrantFiled: December 7, 2001Date of Patent: October 28, 2003Assignee: The Procter & Gamble CompanyInventor: Douglas Joseph Dobrozsi
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Publication number: 20030139437Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: ApplicationFiled: December 20, 1999Publication date: July 24, 2003Inventors: DOUGLAS JOSEPH DOBROZSI, JERRY WILLIAM HAYES, KISHOR JIVANLAL DESAI, BRIAN JAMES ROBBINS
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Publication number: 20030118613Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: ApplicationFiled: December 20, 1999Publication date: June 26, 2003Inventors: DOUGLAS JOSEPH DOBROZSI, JERRY WILLIAM HAYES, KISHOR JIVANLAL DESAI, BRIAN JAMES ROBBINS
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Publication number: 20030113377Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution.Type: ApplicationFiled: October 10, 2001Publication date: June 19, 2003Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, Francis Joseph David Bealin-Kelly, Jayant Eknath khanolkar, Benoit Maurice Mullet, Shane Michael Dela Harpe, Brian James Robbins
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Patent number: 6503955Abstract: The present invention covers pourable liquid vehicles that can be combined with compositions, materials and substances. Among the benefits of such pourable liquid vehicles is the compositions are retained on the moistened surface for a period of time sufficient to allow compositions, materials and substances to act on said surface, resisting erosion or run-off from additional moisture being applied. Such pourable liquid vehicles have a number of utilities including but not limited to cleaning and treating surfaces of objects as well as biological or living organisms, including living creatures.Type: GrantFiled: September 11, 2000Date of Patent: January 7, 2003Assignee: The Procter & Gamble CompanyInventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Bjorn Olof Lindman, Rouja Hristova Ivanova, Paschalis Alexandridis
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Publication number: 20020086878Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: ApplicationFiled: December 20, 1999Publication date: July 4, 2002Inventors: DOUGLAS JOSEPH DOBROZSI, FRANCIS JOSEPH DAVID BEALIN-KELLY
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Publication number: 20020082307Abstract: The present invention pertains to liquid compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives, solvent and a reducing agent. These compositions may take the form of liquid elixirs placed into the mouth by liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.Type: ApplicationFiled: December 20, 1999Publication date: June 27, 2002Inventors: DOUGLAS JOSEPH DOBROZSI, FRANCIS JOSEPH DAVID BEALIN-KELLY, JAYANT EKNATH KHANOLKAR, BRIAN JAMES ROBBINS, RICHARD MATTHEW CHARLES SUTTON
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Publication number: 20020076421Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.Type: ApplicationFiled: December 7, 2001Publication date: June 20, 2002Inventor: Douglas Joseph Dobrozsi
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Publication number: 20020009478Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.Type: ApplicationFiled: July 27, 1999Publication date: January 24, 2002Inventor: DOUGLAS JOSEPH DOBROZSI
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Patent number: 6319513Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal or nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.Type: GrantFiled: July 27, 1999Date of Patent: November 20, 2001Assignee: The Procter & Gamble CompanyInventor: Douglas Joseph Dobrozsi
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Publication number: 20010016577Abstract: The present invention relates to mucoadhesive compositions comprising a safe and effective amount of a gastrointestinal active; from about 1.5% to about 10%, by weight of the composition, of a clay component; and from about 0.01% to about 1%, by weight of the composition, of a gum component. Alternatively, the clay component can be a titanium dioxide or a silicone dioxide component. The mucoadhesive compositions also preferably comprise up to about 2% by weight of the composition, of a non-ionic component such as methyl cellulose. The present invention also relates to methods of prevention and treatment of gastrointestinal tract disorders in humans or lower animals by orally administering a composition of the present invention.Type: ApplicationFiled: July 27, 1999Publication date: August 23, 2001Inventors: DOUGLAS JOSEPH DOBROZSI, TODD EHREN VIENNEAU, CHRISTOPHER ROBERT MAYER, KISHORKUMAR JIVANLAL DESAL
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Patent number: 5670158Abstract: The subject invention involves pharmaceutical compositions in dosage unit form, for peroral administration of bisacodyl to a human or lower animal having a gastrointestinal tract, with a lumen therethrough, with a small intestine and a colon with a junction therebetween, comprising:(a) a safe and effective amount of rapidly-dissolving bisacodyl means; and(b) a delivery means which prevents the release of bisacodyl from the dosage form into the lumen of the gastrointestinal tract during transport of the dosage form through the lumen until the dosage form is near the junction between the small intestine and the colon or in the colon, and which then releases the bisacodyl in the lumen near the junction between the small intestine and the colon or within the colon,The subject invention also involves methods for providing laxation for humans and lower animals in need thereof by peroral administration of such compositions.Type: GrantFiled: November 15, 1995Date of Patent: September 23, 1997Assignee: The Procter & Gamble CompanyInventors: Paula Denise Davis, Douglas Joseph Dobrozsi, Gary Robert Kelm, Kenneth Gary Mandel
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Patent number: 5656290Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material comprising at least one inner coating layer and one outer coating layer;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.Type: GrantFiled: May 17, 1995Date of Patent: August 12, 1997Assignee: The Procter & Gamble CompanyInventors: Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel
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Patent number: 5651983Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.Type: GrantFiled: May 17, 1995Date of Patent: July 29, 1997Assignee: The Procter & Gamble CompanyInventors: Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel, David Lee McCauley-Meyers