Patents by Inventor Douglas Joseph Dobrozsi

Douglas Joseph Dobrozsi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200002703
    Abstract: The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more fungi species from the genus Malassezia.
    Type: Application
    Filed: February 8, 2019
    Publication date: January 2, 2020
    Inventors: Juan Esteban Velasquez, Amy Violet Trejo, Laurie Ellen Breyfogle, James Patrick Henry, Douglas Joseph Dobrozsi, Gregory Allen Penner
  • Publication number: 20180078642
    Abstract: Edible compositions are provided and comprise a soluble mineral component and/or a phosphate component in amounts effective for use as an oral medicament. The soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof. The edible compositions are advantageously companion animal chews, treats or supplements. Further disclosed are methods of making the chews, treats or supplements as are methods of treating conditions of the oral cavity.
    Type: Application
    Filed: November 27, 2017
    Publication date: March 22, 2018
    Applicant: Mars, Incorporated
    Inventors: Edward Russell Cox, Douglas Joseph Dobrozsi, Thomas Edward Huetter, Allan John Lepine, Susan Ruth Ward
  • Patent number: 9827314
    Abstract: Disclosed herein are a variety of embodiments of compositions and methods which are each adapted for use by a companion animal. In one embodiment, an edible composition comprising an amount of a soluble mineral component is disclosed, wherein the soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof, wherein the amount is an effective amount for use as an oral medicament. In further embodiments, a phosphate component is included. The edible compositions are advantageously companion animal foods or supplements. Further disclosed are methods selected from treating oral cavity tartar, oral cavity plaque, periodontal disease, gingivitis, breath odor and combinations thereof comprising orally administering a described composition to a companion animal.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: November 28, 2017
    Assignee: Mars, Incorporated
    Inventors: Edward Russell Cox, Douglas Joseph Dobrozsi, Thomas Edward Huetter, Allan John Lepine, Susan Ruth Ward
  • Patent number: 7138133
    Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: November 21, 2006
    Assignee: The Procter & Gamble Company
    Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Francis Joseph David Bealin-Kelly, Jayant Eknath Khanolkar, Benoit Maurice Mullet, Shane Michael DE LA Harpe, Brian James Robbins
  • Patent number: 6846495
    Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: January 25, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Kishor Jivanlal Desai, Brian James Robbins
  • Patent number: 6638521
    Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: October 28, 2003
    Assignee: The Procter & Gamble Company
    Inventor: Douglas Joseph Dobrozsi
  • Publication number: 20030139437
    Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
    Type: Application
    Filed: December 20, 1999
    Publication date: July 24, 2003
    Inventors: DOUGLAS JOSEPH DOBROZSI, JERRY WILLIAM HAYES, KISHOR JIVANLAL DESAI, BRIAN JAMES ROBBINS
  • Publication number: 20030118613
    Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
    Type: Application
    Filed: December 20, 1999
    Publication date: June 26, 2003
    Inventors: DOUGLAS JOSEPH DOBROZSI, JERRY WILLIAM HAYES, KISHOR JIVANLAL DESAI, BRIAN JAMES ROBBINS
  • Publication number: 20030113377
    Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution.
    Type: Application
    Filed: October 10, 2001
    Publication date: June 19, 2003
    Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, Francis Joseph David Bealin-Kelly, Jayant Eknath khanolkar, Benoit Maurice Mullet, Shane Michael Dela Harpe, Brian James Robbins
  • Patent number: 6503955
    Abstract: The present invention covers pourable liquid vehicles that can be combined with compositions, materials and substances. Among the benefits of such pourable liquid vehicles is the compositions are retained on the moistened surface for a period of time sufficient to allow compositions, materials and substances to act on said surface, resisting erosion or run-off from additional moisture being applied. Such pourable liquid vehicles have a number of utilities including but not limited to cleaning and treating surfaces of objects as well as biological or living organisms, including living creatures.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: January 7, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Douglas Joseph Dobrozsi, Jerry William Hayes, II, Bjorn Olof Lindman, Rouja Hristova Ivanova, Paschalis Alexandridis
  • Publication number: 20020086878
    Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
    Type: Application
    Filed: December 20, 1999
    Publication date: July 4, 2002
    Inventors: DOUGLAS JOSEPH DOBROZSI, FRANCIS JOSEPH DAVID BEALIN-KELLY
  • Publication number: 20020082307
    Abstract: The present invention pertains to liquid compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives, solvent and a reducing agent. These compositions may take the form of liquid elixirs placed into the mouth by liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.
    Type: Application
    Filed: December 20, 1999
    Publication date: June 27, 2002
    Inventors: DOUGLAS JOSEPH DOBROZSI, FRANCIS JOSEPH DAVID BEALIN-KELLY, JAYANT EKNATH KHANOLKAR, BRIAN JAMES ROBBINS, RICHARD MATTHEW CHARLES SUTTON
  • Publication number: 20020076421
    Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.
    Type: Application
    Filed: December 7, 2001
    Publication date: June 20, 2002
    Inventor: Douglas Joseph Dobrozsi
  • Publication number: 20020009478
    Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.
    Type: Application
    Filed: July 27, 1999
    Publication date: January 24, 2002
    Inventor: DOUGLAS JOSEPH DOBROZSI
  • Patent number: 6319513
    Abstract: The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal or nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: November 20, 2001
    Assignee: The Procter & Gamble Company
    Inventor: Douglas Joseph Dobrozsi
  • Publication number: 20010016577
    Abstract: The present invention relates to mucoadhesive compositions comprising a safe and effective amount of a gastrointestinal active; from about 1.5% to about 10%, by weight of the composition, of a clay component; and from about 0.01% to about 1%, by weight of the composition, of a gum component. Alternatively, the clay component can be a titanium dioxide or a silicone dioxide component. The mucoadhesive compositions also preferably comprise up to about 2% by weight of the composition, of a non-ionic component such as methyl cellulose. The present invention also relates to methods of prevention and treatment of gastrointestinal tract disorders in humans or lower animals by orally administering a composition of the present invention.
    Type: Application
    Filed: July 27, 1999
    Publication date: August 23, 2001
    Inventors: DOUGLAS JOSEPH DOBROZSI, TODD EHREN VIENNEAU, CHRISTOPHER ROBERT MAYER, KISHORKUMAR JIVANLAL DESAL
  • Patent number: 5670158
    Abstract: The subject invention involves pharmaceutical compositions in dosage unit form, for peroral administration of bisacodyl to a human or lower animal having a gastrointestinal tract, with a lumen therethrough, with a small intestine and a colon with a junction therebetween, comprising:(a) a safe and effective amount of rapidly-dissolving bisacodyl means; and(b) a delivery means which prevents the release of bisacodyl from the dosage form into the lumen of the gastrointestinal tract during transport of the dosage form through the lumen until the dosage form is near the junction between the small intestine and the colon or in the colon, and which then releases the bisacodyl in the lumen near the junction between the small intestine and the colon or within the colon,The subject invention also involves methods for providing laxation for humans and lower animals in need thereof by peroral administration of such compositions.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: September 23, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Paula Denise Davis, Douglas Joseph Dobrozsi, Gary Robert Kelm, Kenneth Gary Mandel
  • Patent number: 5656290
    Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material comprising at least one inner coating layer and one outer coating layer;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: August 12, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel
  • Patent number: 5651983
    Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: July 29, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel, David Lee McCauley-Meyers