Patent number: 6265374
Abstract: A method of treating inflammation in patients in need of such treatment by administering an effective amount of I-A-B-C-D-E-F-G-H-II (General Formula), wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr, or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, Ile, Leu or absent, E is Ser, Thr, Asp or absent, F is Ser, Thr, Asp or absent, G is Tyr or absent, H is Thr, Arg, Gly, Met, Met(O), Cys, Thr, Gly or absent and I is Cys or absent II is Cys, an amide group, an ester group or absent. At least one of the amino acids optionally is substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino acid and/or amido groups of the amino acids, and wherein the peptide composes at least 4 amino acid residues, and a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
October 20, 1999
Date of Patent:
July 24, 2001
Assignee:
Advanced Immuni T, Inc.
Inventors:
Anders Jorgen Andersen, Roger Aston, Peter Louis Carlen, Penelope Reed Doob, Douglas Kevin MacFadden, David James Phipps, Deborah Rathjen, Fred Widmer
Patent number: 6011014
Abstract: A method of treating or preventing multiple sclerosis in a patients in need of such treatment by administering an effect amount of the peptide: I-A-B-C-D-E-F-G-H-II (General Formula) wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, IIe, Leu or absent, E is Ser, Thr, Asp or absent, F is Thr, Ser, Asn, Glu, Lys, Trp or absent, G is tyr or absent; H is Thr, Arg, Gly, Met, Met(O), Gys, Thr, Gly or absent, I is Cys or absent, II is Cys, an amide group, substituted amide group, an ester group or absent.
Type:
Grant
Filed:
May 21, 1998
Date of Patent:
January 4, 2000
Assignee:
Advanced Immunit, Inc.
Inventors:
Anders Jorgen Andersen, Roger Aston, Peter Louis Carlen, Penelope Reed Doob, Douglas Kevin MacFadden, David James Phipps, Deborah Rathjen, Fred Widmer
Patent number: 5756449
Abstract: A method of treating inflammatory bowel disease in patients in need of such treatment by administering an effective amount of: I-A-B-C-D-E-F-G-H-II (General Formula I), wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr, or absent, C is Ser, Thr or absent. D is Ser, Thr, Asn, Glu, Arg, IIe, Leu or absent, E is Ser, Thr, Asp or absent, F is Ser, Thr, Asp or absent, G is Tyr or absent, H is Thr, Arg, Gly, Met, Met(O), Cys, Thr, Gly or absent, and I is Cys or absent II is Cys, an amide group, substituted amid group, an ester group or absent. At least one of the amino acids optionally being substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino and/or amido groups of the amino acids, and wherein the peptide comprises at least 4 amino acid residues, and a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
February 24, 1995
Date of Patent:
May 26, 1998
Assignees:
Peptide Technology Limited, Drug Royalty Corporation
Inventors:
Anders Jorgen Andersen, Roger Aston, Peter Louis Carlen, Penelope Reed Doob, Douglas Kevin MacFadden, David James Phipps, Deborah Rathjen, Fred Widmer