Abstract: The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

Abstract: The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

Abstract: The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

Abstract: The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

Abstract: A system including a plurality of programmable logic blocks, a plurality of special-purpose blocks, and a configurable high-speed mesh interconnect fabric operatively connecting the plurality of programmable logic blocks and the plurality of special-purpose blocks, where the configurable high-speed mesh interconnect fabric is configured to implement a plurality of interconnect pipeline buses spanning across the system.

Abstract: A system including a plurality of programmable logic blocks, a plurality of special-purpose blocks, and a configurable high-speed mesh interconnect fabric operatively connecting the plurality of programmable logic blocks and the plurality of special-purpose blocks, where the configurable high-speed mesh interconnect fabric is configured to implement a plurality of interconnect pipeline buses spanning across the system.

Abstract: A delay compensator circuit is disclosed to compensate for variations in temperature, supply voltage and process. A monitor circuit is further disclosed that allows the monitoring of the delay of a delay element. The delay compensator circuit and monitor circuit lend themselves easily to the ASIC design methodology since they use conventional ASIC building blocks; namely gates, memory elements and delay elements. The delay compensator and monitor use a time base to track variations in circuit parameters by monitoring the delay through a delay element (delay line or sub-circuit). Compensation may be achieved by switching delays in or out of the circuit to be compensated based on variations of temperature, voltage, and process as measured using the time base. The delay compensator permits the designer to control the output hold time independently of the output delay time. The delay compensator enables a latching device to hold the output signal for the required duration after a reference.

Abstract: A computer network method and apparatus. The present invention comprises a computer network having one or more hubs, each hub comprising one or more connection means for connection of computing devices to the network. Each connection means comprising a first interface means for coupling with a computing device, a second interface means for coupling with the network and a protocol processing means. The protocol processing means receives message packets and, depending on the message type, processing the message as either a network control message or a data transfer message. The present invention provides for "flow through" of data in the case of data transfer messages. The present invention further provides for calculation of checksum bytes as a data packet is received by the protocol processing means.