Abstract: Methods and systems for pharmaceutical compounding are described. In one embodiment a system comprises a solution of a pharmaceutical in an injection vehicle, the solution being contained in a vessel. The system also includes one or more tubes, a filter, and one or more valves. The system presents a sterile environment for compounding the solution.

Abstract: Methods and systems for pharmaceutical compounding are described. In one embodiment a system comprises a solution of a pharmaceutical in an injection vehicle, the solution being contained in a vessel. The system also includes one or more tubes, a filter, and one or more valves. The system presents a sterile environment for compounding the solution.

Abstract: A medicament for administration to a non-human animal, wherein the medicament includes at Least partially hydrolysed protein and one or more pharmacologically active substances. In a preferred embodiment, the protein is derived from meat which is hydrolysed using a fruit-derived proteolytic enzyme such as actinidin from kiwifruit which enhances the palatability of the resulting hydrolysate. A method of manufacturing the medicament, and a method of medicating a non-human animal by administering to the animal a medicament are also disclosed.

Abstract: A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.

Abstract: A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

Abstract: A system and method of enabling detection enhancements selected from a plurality of detection enhancements. In a system having a plurality of clinical rhythms, including a first clinical rhythm, where each of the detection enhancements is associated with the clinical rhythms, the first clinical rhythm is selected. The first clinical rhythm is associated with first and second detection enhancements. When the first clinical rhythm is selected, parameters of the first and second detection enhancements are set automatically. A determination is made as to whether changes are to be made to the parameters. If so, one or more of the parameters are modified under user control.

Abstract: A system and method of enabling detection enhancements selected from a plurality of detection enhancements. In a system having a plurality of clinical rhythms, including a first clinical rhythm, where each of the detection enhancements is associated with the clinical rhythms, the first clinical rhythm is selected. The first clinical rhythm is associated with first and second detection enhancements. When the first clinical rhythm is selected, parameters of the first and second detection enhancements are set automatically. A determination is made as to whether changes are to be made to the parameters. If so, one or more of the parameters are modified under user control.

Abstract: A system comprising a computer and a software module residing in computer memory, where the software module is operable to provide a virtual model of a medical device and to simulate a medical procedure involving the virtual model of the medical device. The virtual model of the medical device includes medical device design parameters. The system also includes a computer interface operable to change design parameters of the virtual model of the medical device in response to simulation of the virtual model in the medical procedure.

Abstract: A testing device and method for a digital video processing system is coupleable to an input and output of the processing system, and inserts video and audio marking information into the input to test system operation. The test device inserts a video marker and an audio marker data code for a single audio channel, preferably in the same digital input frame. The device then monitors the same audio channel and also all the other audio channels at the output, while monitoring for the video marker. The device indicates the occurrence and timing of results that appear at the outputs, the relative timing of the output audio mark(s) versus the video mark, an alarm in the event that an output mark is not found or found on an unexpected channel, etc. The test device successively exercises the audio and video portions of the processing system while also providing numeric timing measurements that are useful for proper setup and operation.

Abstract: A method and apparatus for processing biological signals on an event basis. An event low pass filter (LPF) is provided which passes variations in event features below an event cut-off value, which is analogous to the time-based cutoff frequency. An event high pass filter (HPF) is provided which passes variations in event features that are above an event-rate cutoff. An event variability detector is provided which determines the variation of a discrete variable from values at prior events. An event discriminator is provided for filtering out contributions of unrelated events that are superimposed on a discrete periodic measurement of interest. In all of these techniques, sampling of a biological signal is performed in coincidence with a biological event which does not occur at a constant frequency. In accordance with another aspect, an algorithm is provided using event-based techniques for discriminating abnormal rhythms from normal sinus rhythm on the basis of atrial rate, ventricular rate, and A-V intervals.

Abstract: A cardiac discrimination method in which feature values of a heart related signal (e.g., cardiac biopotentials) determined to be non-baseline are compared with feature values of a heart related signal determined to be normal baseline. The feature values are extracted on an event-basis (a periodically), for obtaining feature values of a complex. For each complex, the feature values form a sequence with the value having the largest absolute value for the sequence given special identity as a fiducial point. The normal baseline complexes' characteristic sequence and a non-baseline complex's sequence are aligned according to the fiducial points, and unoccupied positions on the ends of the sequences resulting from the alignment are filled with zeros to create normal baseline and non-baseline vectors. The similarity value and dissimilarity value of the normalized non-baseline vector with respect to the normalized normal baseline vector are determined.