Patents by Inventor Douglas Lauffenburger

Douglas Lauffenburger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using G-CSF analog compositions
    Patent number: 7402304
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: July 22, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • Methods of using G-CSF analog compositions
    Patent number: 7371370
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: May 13, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger
  • Treatment of tumors expressing mutant EGF receptors
    Publication number: 20070274991
    Abstract: The invention discloses methods of treatment of tumors that express oncogenic forms of the epidermal growth factor receptor (EGFR), such as EGFRvIII. The methods include testing of cancer patients for expression of EGFRvIII in their tumors, followed by treatment with a protein that contains antibody variable regions that recognize specific epitopes on the surface of the EGFR.
    Type: Application
    Filed: March 29, 2007
    Publication date: November 29, 2007
    Inventors: Jeffrey Way, Ginger Chao, Catherine Cresson, Douglas Lauffenburger, K. Wittrup
  • Epidermal growth factor receptor polypeptides and antibodies
    Publication number: 20070009972
    Abstract: Antibodies and polypeptides that bind to and/or modulate the activity of receptors in the epidermal growth factor family are provided herein.
    Type: Application
    Filed: February 16, 2006
    Publication date: January 11, 2007
    Inventors: Ginger Chao, Mark Olsen, Alejandro Wolf-Yadlin, K. Wittrup, Douglas Lauffenburger
  • Use of bayesian networks for modeling cell signaling systems
    Publication number: 20070009923
    Abstract: Methods of developing and using models of cellular networks by applying a probabilistic graphical model are provided.
    Type: Application
    Filed: January 24, 2006
    Publication date: January 11, 2007
    Applicants: Massachusetts Institute of Technology, The Board of Trustees of the Leland Stanford Jonior University
    Inventors: Garry Nolan, Omar Perez, Karen Sachs, Douglas Lauffenburger
  • G-CSF analog compositions and methods
    Patent number: 6946548
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 20, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • Mutant interleukin-2 (IL-2) polypeptides
    Publication number: 20050142106
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Application
    Filed: July 19, 2004
    Publication date: June 30, 2005
    Inventors: K. Wittrup, Balaji Rao, Douglas Lauffenburger
  • G-CSF analog compositions and methods
    Publication number: 20050123508
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Application
    Filed: January 31, 2005
    Publication date: June 9, 2005
    Inventors: Casim Sarkar, Douglas Lauffenburger, Bruce Tidor
  • G-CSF analog compositions and methods
    Publication number: 20050003453
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Application
    Filed: August 3, 2004
    Publication date: January 6, 2005
    Inventors: Casim Sarkar, Douglas Lauffenburger
  • Method for screening analogs of G-CSF
    Patent number: 6790628
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 14, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger
  • G-CSF analog compositions and methods
    Publication number: 20030166527
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) analog polypeptide compositions, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the present G-CSF analogs. The concept detailed herein involves novel mutants of G-CSF, using single substitutions to amino acids, which were rationally chosen to affect the cellular trafficking of G-CSF and/or G-CSFR. In addition, pharmaceutical compositions, and methods of use are provided.
    Type: Application
    Filed: September 10, 2001
    Publication date: September 4, 2003
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger, Bruce Tidor
  • G-CSF analog compositions and methods
    Publication number: 20020151488
    Abstract: The present invention relates to granulocyte colony stimulating factor (“G-CSF”) polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use as G-CSF replacements or antagonists, and may be generalizable beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.
    Type: Application
    Filed: September 10, 2001
    Publication date: October 17, 2002
    Inventors: Casim A. Sarkar, Douglas A. Lauffenburger