Abstract: The present disclosure provides compositions with enhanced bioactivity and methods of use in the treatment of disease or tissue injury and pain associated with disease conditions.

Abstract: Provided herein is a centrifuge chamber, useful in the separation and concentration of particles from cell suspensions. In particular, the centrifuge chamber described herein can be advantageously used to separate and concentrate desired cell populations from cell suspensions, e.g., from biological samples or tissues. Also provided are methods of separating and concentrating desired particles (e.g., desired cell populations), from suspensions (e.g., cell suspensions) using the centrifuge chamber described herein. Kits including a centrifuge chamber as described herein, and optionally other components (e.g., a centrifuge), are also provided.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: Described herein are devices for the transfer of tissue into tissue processing devices. In some embodiments, the devices provide for the transfer of tissue from a tissue collection vessel to a tissue processing vessel. In some embodiments, the devices and methods provide for direct harvest of the tissue into a tissue processing vessel. In some embodiments, the devices and methods provide for transfer of harvested tissue within a tissue collection container to a tissue processing container.

Abstract: A medical instrument is disclosed that includes an elongated probe section having a length (L) between a proximal and a distal probe section end. The probe section includes a plurality of carbon fibers that is arrayed along the axis and embedded in a medical grade, biocompatible epoxy resin. The probe section is constructed to be rigid by controlling the density of carbon fibers such that the maximum predetermined off-axis deflection (dmax) is less than about 30% of the probe section length (dmax<0.3 L). A handle is affixed, and positioned to be coaxial with, the proximal end of the probe section. For the instrument, the probe section is constructed of materials that are impervious to an imaging modality (e.g. magnetic fields). For example, with this construction, the probe section can be immersed in a homogenous magnetic field that is established by an MRI system without distorting the resulting MRI image.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: A cell suspension that contains a cell group from which unwanted components have been removed by efficiently washing the cell group is recovered. A centrifuge container (1) includes a cylindrical container main body (2) that accommodates a cell suspension and is rotated with a bottom portion (2a) being directed radially outward; a supernatant suction tube (4) that has a first opening (4a) at a position in the depth direction of the container main body (2) and that suctions a supernatant obtained by centrifuging the cell suspension, in the radial direction of the container main body (2); and a washing-fluid discharge tube (3) that have a second opening (3a) at a position in the depth direction of the container main body (2) and that discharge a washing fluid in the axial direction toward the bottom portion (2a) of the container main body (2).

Abstract: The count of cells that are to be concentrated in a centrifugal container and transplanted can be measured without damaging these cells. Disclosed is a cell processing device comprising: a centrifugal separator which concentrates cells by rotating a centrifugal container that contains a cell suspension yielded by digestion of a biological tissue; a property detection unit which detects a property of the cell suspension contained in the centrifugal container of the centrifugal separator; and a cell count enumeration unit which calculates the cell count on the basis of the property of the cell suspension detected by the property detection unit.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.

Abstract: The invention provides for dispensing a bone substitute material, comprising: an elongated body having an outer wall, a front opening, and a rear opening, with the outer wall defining a longitudinally extending interior space therein. The invention also includes a cover for the front opening having a sealable opening therein to allow substances to pass through the opening. A plunger sized to slide within the longitudinally extending cavity divides the cavity into first and second portions. The plunger preferably has a small opening therein to allow passage of fluids (including gases), from the longitudinally extending interior space without permitting solids to pass therethrough. A detachable handle connects to the plunger for sliding the plunger toward or away from the front opening.