Patents by Inventor Douglas M. Tollefsen

Douglas M. Tollefsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified heparin cofactor II
    Patent number: 5118793
    Abstract: A modified heparin cofactor II is disclosed, HCII(Leu.sub.444 .fwdarw.Arg), which has substantially improved inhibitory activity against thrombin compared to native HCII or antithrombin.
    Type: Grant
    Filed: November 14, 1991
    Date of Patent: June 2, 1992
    Assignee: Washington University
    Inventors: Douglas M. Tollefsen, Vivianna M. Derechin, Morey A. Blinder
  • DNA encoding modified heparin cofactor II
    Patent number: 5102995
    Abstract: A modified heparin cofactor II is disclosed, HCII (Leu.sub.444 .fwdarw.Arg), which has substantially improved inhibitory activity against thrombin compared to native HCII or antithrombin.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: April 7, 1992
    Assignee: Washington University
    Inventors: Douglas M. Tollefsen, Vivianna M. Derechin, Morey A. Blinder