Abstract: A lowerable window in an automotive vehicle has a guide and sealing system with a guide member attached substantially along the length of an edge of the window pane so as not to overlap with the outer surface thereof, the guide member having a guide conduit for interaction with a door channel having two prongs extending from vehicle door panels which define a channel portion therebetween. A guide member and the door channel are interposed such that the guide member receives a first prong of the door channel within the guide conduit and the door channel receives a guide edge within the channel portion. A seal member is mounted on the door channel so as to substantially fill a space between the guide edge and the first prong, and has at least three lip members, two of which extend laterally outward from the two prongs of the door channel so as to contact inward facing surfaces of the guide member.