Abstract: An occlusion device having a lumen defined therethrough and a saddle narrower than saddles of prior occlusion devices or stents to allow provision of an occlusion element with respect to a portion of the saddle to occlude flow of materials through the saddle. The inner diameter of the narrowed saddle may be 6 mm or less. The occlusion element may be formed from a material which plugs a portion of the occlusion device lumen extending through the saddle and/or which restrains a portion of the saddle from expanding thereby occluding flow of materials therethrough. The remainder of the saddle and/or inwardly facing surfaces of at least one retention member extending outwardly along an end of the saddle may be configured to promote tissue ingrowth, such as by remaining uncoated.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: A system for measuring a pressure in a vein includes a needle sized and shaped to be inserted through a working channel of an endoscope. The needle is extending longitudinally and including a channel extending longitudinally therethrough. The system also includes a pressure sensing device including a longitudinally extending body sized and shaped to be slidably inserted through the channel of the needle and a sensor mounted on a distal portion of the body and connected to a proximal portion of the pressure sensing device via a connection cable. The sensor is configured to detect information corresponding to a pressure of a flow of blood through a vein.

Abstract: An endoscopic tissue fastening device may include a body having a first portion and a second portion arranged alongside the first portion. The second portion may extend distally of the first portion and may terminate in a distal end face of the body. The device may further include a tissue fastening assembly having a fastening head with a proximal end and a distal end. The fastening head may be deflectable at a location between the proximal end and the distal end of the fastening head. The tissue fastening assembly may be received within a lumen of the body. Further, the body may be moveable between an unarticulated configuration and an articulated configuration. In the articulated configuration, a central longitudinal axis of the second portion of the body may be substantially parallel with a central longitudinal axis of the tissue fastening assembly.

Abstract: A system for measuring a pressure in a vein includes a needle sized and shaped to be inserted through a working channel of an endoscope. The needle is extending longitudinally and including a channel extending longitudinally therethrough. The system also includes a pressure sensing device including a longitudinally extending body sized and shaped to be slidably inserted through the channel of the needle and a sensor mounted on a distal portion of the body and connected to a proximal portion of the pressure sensing device via a connection cable. The sensor is configured to detect information corresponding to a pressure of a flow of blood through a vein.

Abstract: An endoscopic tissue fastening device may include a body having a first portion and a second portion arranged alongside the first portion. The second portion may extend distally of the first portion and may terminate in a distal end face of the body. The device may further include a tissue fastening assembly having a fastening head with a proximal end and a distal end. The fastening head may be deflectable at a location between the proximal end and the distal end of the fastening head. The tissue fastening assembly may be received within a lumen of the body. Further, the body may be moveable between an unarticulated configuration and an articulated configuration. In the articulated configuration, a central longitudinal axis of the second portion of the body may be substantially parallel with a central longitudinal axis of the tissue fastening assembly.

Abstract: A medical device that comprises a rim defining a loop in a plane and defining a width measured perpendicular to the plane, at least one wire coupled to a distal end of the rim and extending proximally from the distal end out of the plane to a proximal end of the rim, the at least one wire having a cross-sectional dimension measured perpendicular to a longitudinal axis of the at least one wire, the cross-sectional dimension being smaller than the width of the rim, and a sheath configured to cover at least a portion of the rim and a portion of the at least one wire.

Abstract: A medical device that comprises a rim defining a loop in a plane and defining a width measured perpendicular to the plane, at least one wire coupled to a distal end of the rim and extending proximally from the distal end out of the plane to a proximal end of the rim, the at least one wire having a cross-sectional dimension measured perpendicular to a longitudinal axis of the at least one wire, the cross-sectional dimension being smaller than the width of the rim, and a sheath configured to cover at least a portion of the rim and a portion of the at least one ware.

Abstract: The present disclosure relates generally to medical devices and procedures for placement of a medical device between adjacent tissue structures. In particular, the present disclosure relates to endoscopic systems and methods for preventing or minimizing movement between tissue walls to facilitate placement of a stent therebetween.

Abstract: According to exemplary embodiments of the present disclosure, devices, systems, and methods for pyloric occlusion in an endoscopic procedure may include a first flange and a second flange connected to the first flange by a saddle region having a lumen. The second flange may be proximal to the first flange. The pyloric occlusion device may further include a closure element. The closure element may be configured to occlude a flow of material through the lumen, including across the pylorus when deployed. The closure element may be a closure of the lumen by rotation of one of the first or second flanges about the saddle region relative to the other of the first or second flange.

Abstract: A medical assembly may comprise an end effector; a sheath; and a device coupler. The device coupler may include a proximal support, a distal support, and a coupler arm extending between the proximal support and the distal support. The coupler arm may include a surface configured to accommodate a shape of a medical device resting upon the coupler arm. The end effector may be attached to the distal support, and the proximal support may be attached to the sheath.

Abstract: The present disclosure relates generally to medical devices and procedures for placement of a medical device between adjacent tissue structures. In particular, the present disclosure relates to endoscopic systems and methods for preventing or minimizing movement between tissue walls to facilitate placement of a stent therebetween.

Abstract: According to exemplary embodiments of the present disclosure, devices, systems, and methods for pyloric occlusion in an endoscopic procedure may include a first flange and a second flange connected to the first flange by a saddle region having a lumen. The second flange may be proximal to the first flange. The pyloric occlusion device may further include a closure element. The closure element may be configured to occlude a flow of material through the lumen, including across the pylorus when deployed. The closure element may be a closure of the lumen by rotation of one of the first or second flanges about the saddle region relative to the other of the first or second flange.

Abstract: A fastening mechanism that comprises an actuator, a fastening device attached to a distal end of the actuator, and a device coupler, wherein the fastening device is pivotally attached to the device coupler.

Abstract: A coupling device for a medical system includes a first portion and a second portion. The first portion includes a first body and a first connector. The first connector extends from the first body and is configured to couple a first medical device to the first portion. The second portion includes a second body and a second connector. The second connector extends from the second body and is configured to couple a second medical device to the second portion. The first portion and the second portion are removably couplable, and, when coupled, the second portion are rotatable relative to the first portion.

Abstract: An anchor capable of being delivered in a delivery configuration and deployed through anatomical tissue with the use of a delivery device. Upon deployment, the anchor shifts into a deployment configuration with at least a distal anchor portion extending transverse to a medial portion of the anchor. The anchor is removable from the anatomical tissue with the use of a retrieval device which grasps a proximal end of the anchor and proximally retracts the anchor into a flexible tubular element to return the anchor to the delivery configuration.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: An endoscopic tissue fastening device may include a body having a first portion and a second portion arranged alongside the first portion. The second portion may extend distally of the first portion and may terminate in a distal end face of the body. The device may further include a tissue fastening assembly having a fastening head with a proximal end and a distal end. The fastening head may be deflectable at a location between the proximal end and the distal end of the fastening head. The tissue fastening assembly may be received within a lumen of the body. Further, the body may be moveable between an unarticulated configuration and an articulated configuration. In the articulated configuration, a central longitudinal axis of the second portion of the body may be substantially parallel with a central longitudinal axis of the tissue fastening assembly.

Abstract: An endoscopic tissue fastening device may include a body having a first portion and a second portion arranged alongside the first portion. The second portion may extend distally of the first portion and may terminate in a distal end face of the body. The device may further include a tissue fastening assembly having a fastening head with a proximal end and a distal end. The fastening head may be deflectable at a location between the proximal end and the distal end of the fastening head. The tissue fastening assembly may be received within a lumen of the body. Further, the body may be moveable between an unarticulated configuration and an articulated configuration. In the articulated configuration, a central longitudinal axis of the second portion of the body may be substantially parallel with a central longitudinal axis of the tissue fastening assembly.