Patents by Inventor Douglas N. Modlin
Douglas N. Modlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9156010Abstract: Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.Type: GrantFiled: September 23, 2009Date of Patent: October 13, 2015Assignee: Bio-Rad Laboratories, Inc.Inventors: Billy Wayne Colston, Jr., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier, Fred Paul Milanovich, Douglas N. Modlin, Vincent Riot, Samuel Burd, Anthony Joseph Makarewicz, Jr., Phillip Belgrader
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Publication number: 20100173394Abstract: Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.Type: ApplicationFiled: September 23, 2009Publication date: July 8, 2010Inventors: Billy Wayne Colston, JR., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier, Fred Paul Milanovich, Douglas N. Modlin, Vincent Riot, Samuel Burd, Anthony Joseph Makarewicz, JR., Phillip Belgrader
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Patent number: 7736906Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodologies.Type: GrantFiled: June 17, 2002Date of Patent: June 15, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Patent number: 7691330Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: May 26, 2000Date of Patent: April 6, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Patent number: 7349223Abstract: Several embodiments of enhanced integrated circuit probe card and package assemblies are disclosed, which extend the mechanical compliance of both MEMS and thin-film fabricated probes, such that these types of spring probe structures can be used to test one or more integrated circuits on a semiconductor wafer. Several embodiments of probe card assemblies, which provide tight signal pad pitch compliance and/or enable high levels of parallel testing in commercial wafer probing equipment, are disclosed. In some preferred embodiments, the probe card assembly structures include separable standard components, which reduce assembly manufacturing cost and manufacturing time. These structures and assemblies enable high speed testing in wafer form. The probes also have built in mechanical protection for both the integrated circuits and the MEMS or thin film fabricated spring tips and probe layout structures on substrates.Type: GrantFiled: June 16, 2004Date of Patent: March 25, 2008Assignee: Nanonexus, Inc.Inventors: Joseph Michael Haemer, Fu Chiung Chong, Douglas N. Modlin
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Patent number: 6992761Abstract: Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/or successive analysis of different samples, and particularly when the sample or samples have a wide range of light intensities. These systems also may include apparatus and methods for detecting light with increased accuracy over a broad range of intensities. These systems also may include vapparatus and methods for automatically scaling detection range to improve detection based on the intensity of the detected light.Type: GrantFiled: May 22, 2003Date of Patent: January 31, 2006Assignee: Molecular Devices CorporationInventors: Douglas N. Modlin, David P. Stumbo, Rick V. Stellmacher, Jonathan F. Petersen, Todd E. French
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Patent number: 6982431Abstract: Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates.Type: GrantFiled: August 13, 2002Date of Patent: January 3, 2006Assignee: Molecular Devices CorporationInventors: Douglas N. Modlin, Glenn R. Edwards, John C. Owicki, Michael T. Taylor, Samuel A. Marquiss
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Patent number: 6943034Abstract: A method for producing arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a compound in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the compound to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: February 4, 2000Date of Patent: September 13, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Patent number: 6902703Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: GrantFiled: February 5, 2001Date of Patent: June 7, 2005Assignee: LJL Biosystems, Inc.Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Lev J. Leytes, Samuel Burd
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Patent number: 6864101Abstract: A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 polymer ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: May 26, 2000Date of Patent: March 8, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Patent number: 6849462Abstract: A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.Type: GrantFiled: May 26, 2000Date of Patent: February 1, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Patent number: 6838051Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: GrantFiled: February 6, 2001Date of Patent: January 4, 2005Assignee: LJL BioSystems, Inc.Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Ley J. Leytes, Samuel Burd
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Publication number: 20040239922Abstract: Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/or successive analysis of different samples, and particularly when the sample or samples have a wide range of light intensities. These systems also may include apparatus and methods for detecting light with increased accuracy over a broad range of intensities. These systems also may include vapparatus and methods for automatically scaling detection range to improve detection based on the intensity of the detected light.Type: ApplicationFiled: May 22, 2003Publication date: December 2, 2004Inventors: Douglas N. Modlin, David P. Stumbo, Rick V. Stellmacher, Jonathan F. Petersen, Todd E. French
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Patent number: 6825921Abstract: Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the composition using the multi-mode instrument in a first optical measurement mode; (3) detecting light transmitted from the composition using the multi-mode instrument in a second optical measurement mode, the second mode being different than the first mode; and (4) computing a quantity related to a property of the composition using the light detected in at least one of the optical measurement modes. These steps may be performed on one or more samples, simultaneously and/or sequentially. The quantity may relate to photoluminescence, chemiluminescence, absorption, and/or scattering, among others.Type: GrantFiled: November 10, 2000Date of Patent: November 30, 2004Assignee: Molecular Devices CorporationInventors: Douglas N. Modlin, John C. Owicki, Jon F. Petersen, Todd E. French, Carl L. Wright, Jeanne A. Ruiz, Lorne E. Bechtel
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Publication number: 20040235033Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.Type: ApplicationFiled: May 14, 2004Publication date: November 25, 2004Applicant: Affymetrix, Inc.Inventors: Alejandro C. Zaffaroni, Christopher J. Buchko, Douglas N. Modlin
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Publication number: 20040223309Abstract: Several embodiments of enhanced integrated circuit probe card and package assemblies are disclosed, which extend the mechanical compliance of both MEMS and thin-film fabricated probes, such that these types of spring probe structures can be used to test one or more integrated circuits on a semiconductor wafer. Several embodiments of probe card assemblies, which provide tight signal pad pitch compliance and/or enable high levels of parallel testing in commercial wafer probing equipment, are disclosed. In some preferred embodiments, the probe card assembly structures include separable standard components, which reduce assembly manufacturing cost and manufacturing time. These structures and assemblies enable high speed testing in wafer form. The probes also have built in mechanical protection for both the integrated circuits and the MEMS or thin film fabricated spring tips and probe layout structures on substrates.Type: ApplicationFiled: June 16, 2004Publication date: November 11, 2004Inventors: Joseph Michael Haemer, Fu Chiung Chong, Douglas N. Modlin
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Publication number: 20040092032Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: June 17, 2002Publication date: May 13, 2004Applicant: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P.A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
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Publication number: 20030205681Abstract: Devices and methods are disclosed comprising providing a sample holder having a plurality of sample wells. Inner and outer surfaces of at least one well are configured for total internal reflection of incident light.Type: ApplicationFiled: January 12, 2001Publication date: November 6, 2003Applicant: LJL BioSystems, Inc.Inventor: Douglas N. Modlin
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Publication number: 20030127609Abstract: Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates.Type: ApplicationFiled: August 13, 2002Publication date: July 10, 2003Inventors: Amer El-Hage, Christopher G. Cesar, Douglas N. Modlin, Glenn R. Edwards, John C. Owicki, Joh W. Meadows, Michael T. Taylor, Samuel A. Marquiss, Jonathan F. Petersen, David P. Stumbo
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Patent number: 6576476Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.Type: GrantFiled: April 29, 1999Date of Patent: June 10, 2003Assignee: LJL BioSystems, Inc.Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin