Patents by Inventor Douglas Patton Kjell

Douglas Patton Kjell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of selective estrogen receptor degraders
    Patent number: 11926634
    Abstract: Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, —CF3, or —CH3, and the other is H; and R7 is H or PG.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: March 12, 2024
    Assignee: Eli Lilly and Company
    Inventors: Alonso Jose Arguelles Delgado, Boris Arnoldovich Czeskis, Mai Khanh Nguyen Hawk, Douglas Patton Kjell, Yu Lu, Nicholas Andrew Magnus, David Michael Remick
  • PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS
    Publication number: 20230242545
    Abstract: Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, —CF3, or —CH3, and the other is H; and R7 is H or PG.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 3, 2023
    Inventors: Alonso Jose ARGUELLES DELGADO, Boris Arnoldovich CZESKIS, Mai Khanh Nguyen HAWK, Douglas Patton KJELL, Yu LU, Nicholas Andrew MAGNUS, David Michael REMICK
  • Process and intermediates for preparing arzoxifene
    Patent number: 8124776
    Abstract: The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combine to form morpholino; and processes to prepare arzoxifene.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: February 28, 2012
    Assignee: Eli Lilly and Company
    Inventors: Charles Arthur Alt, Douglas Patton Kjell, Tony Yantao Zhang, Fu-Yao Zhang, Jared Wade Fennell, Kevin Dale Seibert
  • PROCESS AND INTERMEDIATES FOR PREPARING ARZOXIFENE
    Publication number: 20100137602
    Abstract: The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combine to form morpholino; and processes to prepare arzoxifene.
    Type: Application
    Filed: March 3, 2008
    Publication date: June 3, 2010
    Inventors: Charles Arthur Alt, Douglas Patton Kjell, Tony Yantao Zhang, Fu-Yao Zhang, Jared Wade Fennell, Kevin Dale Siebert
  • Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof
    Patent number: 6541668
    Abstract: The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: April 1, 2003
    Assignee: Eli Lilly and Company
    Inventors: Douglas Patton Kjell, Kurt Thomas Lorenz
  • Processes and intermediates useful to make antifolates
    Publication number: 20010011142
    Abstract: The present application relates to a series of novel sulfonic acid metal cation salts of the formula 1
    Type: Application
    Filed: February 15, 2000
    Publication date: August 2, 2001
    Inventor: Douglas Patton Kjell
  • Processes and intermediates useful to make antifolates
    Patent number: 6262262
    Abstract: The present application relates to a series of novel sulfonic acid metal cation salts of the formula which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula from the corresponding sulfonic acid metal cation salts.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: July 17, 2001
    Assignee: Eli Lilly and Company
    Inventor: Douglas Patton Kjell
  • Processes and intermediates useful to make antifolates
    Patent number: 6090168
    Abstract: The present application relates to a series of novel sulfonic acid metal cation salts of the formula ##STR1## which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula ##STR2## from the corresponding sulfonic acid metal cation salts.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Douglas Patton Kjell, Brian James Slattery, Charles Jackson Barnett
  • Processes and intermediates useful to make antifolates
    Patent number: 6013828
    Abstract: The present application relates to a series of novel sulfonic acid metal cation salts of the formula ##STR1## which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula ##STR2## from the corresponding sulfonic acid metal cation salts.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: January 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Douglas Patton Kjell, Brian James Slattery, Charles Jackson Barnett