Abstract: A time-release nutritional dietary supplement in a pharmaceutically acceptable vehicle for ingestion. The nutritional supplement is held or bound within the cross-linked structure of hydrophilic resin particles or beads. The selection of percent cross-linking of the resin particles and the selected quantity of the nutritional supplement loaded into that cross-linked structure will determine the time period over which the nutritional supplement is released after ingestion. Embodiments of this invention may include acid-sensitive and acid-insensitive nutrient supplements. Prior to mixture loading of an acid-sensitive supplement into the resin particles, the resin may be ion exchanged with a soluble monovalent salt formed, for example, of Li or K which enables the modified resin particles to be loaded with the acid-sensitive nutritional supplement without damage.