Patents by Inventor Douglas R. Hole
Douglas R. Hole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10987377Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.Type: GrantFiled: January 31, 2018Date of Patent: April 27, 2021Assignee: Advanced Inhalation Therapies (AIT), Ltd.Inventors: Bruce R. Murray, Christopher C. Miller, Douglas R. Hole, Bryan Perry
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Publication number: 20180250329Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.Type: ApplicationFiled: January 31, 2018Publication date: September 6, 2018Inventors: Bruce R. Murray, Christopher C. Miller, Douglas R. Hole, Bryan Perry
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Publication number: 20160194766Abstract: Devices and methods are described for converting a carbon source and a hydrogen source into hydrocarbons, such as alcohols, for alternative energy sources. The influents may comprise carbon dioxide gas and hydrogen gas or water, obtainable from the atmosphere for through methods described herein, such as plasma generation or electrolysis. One method to produce hydrocarbons comprises the use of an electrolytic device, comprising an anode, a cathode and an electrolyte. Another method comprises the use of ultrasonic energy to drive the reaction. The devices and methods and related devices and methods are useful, for example, to provide a fossil fuel alternative energy source, store renewable energy, sequester carbon dioxide from the atmosphere, counteract global warming, and store carbon dioxide in a liquid fuel.Type: ApplicationFiled: March 15, 2016Publication date: July 7, 2016Inventors: Craig D. Eastman, Douglas R. Hole
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Patent number: 9315910Abstract: Devices and methods are described for converting a carbon source and a hydrogen source into hydrocarbons, such as alcohols, for alternative energy sources. The influents may comprise carbon dioxide gas and hydrogen gas or water, obtainable from the atmosphere for through methods described herein, such as plasma generation or electrolysis. One method to produce hydrocarbons comprises the use of an electrolytic device, comprising an anode, a cathode and an electrolyte. Another method comprises the use of ultrasonic energy to drive the reaction. The devices and methods and related devices and methods are useful, for example, to provide a fossil fuel alternative energy source, store renewable energy, sequester carbon dioxide from the atmosphere, counteract global warming, and store carbon dioxide in a liquid fuel.Type: GrantFiled: August 28, 2012Date of Patent: April 19, 2016Assignee: Principle Energy Solutions Inc.Inventors: Craig D. Eastman, Douglas R. Hole
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Publication number: 20140141098Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.Type: ApplicationFiled: August 26, 2013Publication date: May 22, 2014Applicant: Pulmonox Technologies CorporationInventors: Bruce R. Murray, Christopher C. Miller, Douglas R. Hole
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Patent number: 8518457Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.Type: GrantFiled: November 10, 2006Date of Patent: August 27, 2013Assignee: Pulmonox Technologies CorporationInventors: Christopher C. Miller, Douglas R. Hole, Bruce R Murray, Bryan Perry
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Publication number: 20120329657Abstract: Devices and methods are described for converting a carbon source and a hydrogen source into hydrocarbons, such as alcohols, for alternative energy sources. The influents may comprise carbon dioxide gas and hydrogen gas or water, obtainable from the atmosphere for through methods described herein, such as plasma generation or electrolysis. One method to produce hydrocarbons comprises the use of an electrolytic device, comprising an anode, a cathode and an electrolyte. Another method comprises the use of ultrasonic energy to drive the reaction. The devices and methods and related devices and methods are useful, for example, to provide a fossil fuel alternative energy source, store renewable energy, sequester carbon dioxide from the atmosphere, counteract global warming, and store carbon dioxide in a liquid fuel.Type: ApplicationFiled: August 28, 2012Publication date: December 27, 2012Applicant: PRINCIPLE ENERGY SOLUTIONS, INC.Inventors: Craig D. Eastman, Douglas R. Hole
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Patent number: 8277631Abstract: Devices and methods are described for converting a carbon source and a hydrogen source into hydrocarbons, such as alcohols, for alternative energy sources. The influents may comprise carbon dioxide gas and hydrogen gas or water, obtainable from the atmosphere for through methods described herein, such as plasma generation or electrolysis. One method to produce hydrocarbons comprises the use of an electrolytic device, comprising an anode, a cathode and an electrolyte. Another method comprises the use of ultrasonic energy to drive the reaction. The devices and methods and related devices and methods are useful, for example, to provide a fossil fuel alternative energy source, store renewable energy, sequester carbon dioxide from the atmosphere, counteract global warming, and store carbon dioxide in a liquid fuel.Type: GrantFiled: May 5, 2008Date of Patent: October 2, 2012Assignee: Principle Energy Solutions, Inc.Inventors: Craig D. Eastman, Douglas R. Hole
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Publication number: 20120186635Abstract: Devices and methods are described for more effectively collecting solar energy, including both visible and non-visible electromagnetic radiation to be converted into electrical energy. For example, a nanotube/nanowire device, comprising an electrical contact layer, semi-conductive layer, insulating layer, source electrode, drain electrode and semi-conducting nanotubes/nanowires can be used to collect solar energy from the UV to the infrared electromagnetic spectrum. Another example comprises a device that is capable of adjusting its frequency response to maximize power output according to the wavelength of electromagnetic radiation present. These devices and related methods are useful, for example, to provide an alternative electrical energy source, harness unused renewable energy, reduce carbon dioxide emissions, counteract global warming, and provide a carbon neutral energy source.Type: ApplicationFiled: January 26, 2012Publication date: July 26, 2012Inventors: Craig D. Eastman, Douglas R. Hole
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Publication number: 20120118287Abstract: Gas packages for the delivery of therapeutic gases, and in particular gaseous nitric oxide (gNO) are provided herein. The gas packages comprise one or more of a gas reservoir, interface layer, sealing layer, and holding container. The interface layer regulates discharge of the therapeutic gas from the gas reservoir to the external environment. The sealing layer and/or holding container prevent evolution of the gas until the sealing layer is compromised or the holding container is opened.Type: ApplicationFiled: November 4, 2011Publication date: May 17, 2012Applicant: PULMONOX TECHNOLOGIES CORPORATIONInventors: Douglas R. Hole, Curtis Figley, Robert E. Lee, Michael Hudec, Robert Rolfson
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Patent number: 8079998Abstract: Gas packages for the delivery of therapeutic gases, and in particular gaseous nitric oxide (gNO) are provided herein. The gas packages comprise one or more of a gas reservoir, interface layer, sealing layer, and holding container. The interface layer regulates discharge of the therapeutic gas from the gas reservoir to the external environment. The sealing layer and/or holding container prevent evolution of the gas until the sealing layer is compromised or the holding container is opened. The gas packages and methods for using them are useful for the treatment, alleviation, and prevention of various disease and non-disease, medical and non-medical, conditions in humans and animals.Type: GrantFiled: March 2, 2007Date of Patent: December 20, 2011Assignee: Pulmonox Technologies CorporationInventors: Douglas R. Hole, Curtis Figley, Robert E. Lee, Michael Hudec, Robert Rolfson
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Publication number: 20080283411Abstract: Devices and methods are described for converting a carbon source and a hydrogen source into hydrocarbons, such as alcohols, for alternative energy sources. The influents may comprise carbon dioxide gas and hydrogen gas or water, obtainable from the atmosphere for through methods described herein, such as plasma generation or electrolysis. One method to produce hydrocarbons comprises the use of an electrolytic device, comprising an anode, a cathode and an electrolyte. Another method comprises the use of ultrasonic energy to drive the reaction. The devices and methods and related devices and methods are useful, for example, to provide a fossil fuel alternative energy source, store renewable energy, sequester carbon dioxide from the atmosphere, counteract global warming, and store carbon dioxide in a liquid fuel.Type: ApplicationFiled: May 5, 2008Publication date: November 20, 2008Inventors: Craig D. Eastman, Douglas R. Hole
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Publication number: 20080193566Abstract: The invention relates to a methods and devices of delivering gaseous nitric oxide to a mammal or surface at a concentration ranging from about 1000 ppm to about 50,000 ppm of gaseous nitric oxide. Different conditions which can be treated by high dosage administration of gNO include but are not limited to: topical treatments with gNO, cosmetic applications of gNO, vasodilation conditions with gNO, inhalation treatments with gNO, treatments of the blood with gNO, treatment of the skin or tissue with gNO, treatment of infections with gNO, treatment of inflammation on or within the body, and treatments of biofilms with gNO. Other conditions, aliments, or symptoms that may be treated with high dosage gNO include bronchoconstriction, reversible pulmonary vasoconstriction, asthma, pulmonary hypertension, adult respiratory distress syndrome (ARDS), and persistent pulmonary hypertension of the newborn (PPHN).Type: ApplicationFiled: February 9, 2007Publication date: August 14, 2008Inventors: Christopher C. Miller, Douglas R. Hole, Robert E. Lee
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Publication number: 20020138051Abstract: A system and a method topically applies nitric oxide to an infected area of tissue to treat a wound or lesion to prevent infection, reduce pathogen levels in the infected area and promote healing. The basic system includes a source of nitric oxide gas and a flushing envelope. The flushing envelope is applied to an animal to cover a wound and receives nitric oxide from the source via a flow control valve. One form of the system includes a vacuum unit fluidically connected to the flushing envelope, and one embodiment includes a gas absorber unit. The flushing envelope is adapted to surround the area of the infected tissue and form a substantially air-tight seal with the tissue surface when the flushing envelope is in place on the animal. The flow control valve controls the amount and concentration of nitric oxide gas that is delivered to the flushing envelope.Type: ApplicationFiled: March 26, 2001Publication date: September 26, 2002Inventors: Douglas R. Hole, Cortis Figley, Christopher C. Miller, Alex Stenller