Patents by Inventor Douglas R. Swanson
Douglas R. Swanson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7985424Abstract: Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials.Type: GrantFiled: December 21, 2005Date of Patent: July 26, 2011Assignee: Dendritic Nanotechnologies Inc.Inventors: Donald A. Tomalia, Douglas R. Swanson, Baohua Huang, Veera Reddy Pulgam, Joseph R. Heinzelmann, Sonke Svenson, Lori A. Reyna, Michael A. Zhuravel, Abhay Singh Chauhan, Cordell R. DeMattei
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Patent number: 7981444Abstract: Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.Type: GrantFiled: April 20, 2005Date of Patent: July 19, 2011Assignee: Dendritic Nanotechnologies, Inc.Inventors: Donald A. Tomalia, Douglas R. Swanson, Baohua Huang, Veera Reddy Pulgam
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Patent number: 7977452Abstract: This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which may be used as intermediates to make the Janus dendrimers or to further react with another reactive moiety.Type: GrantFiled: March 27, 2006Date of Patent: July 12, 2011Assignee: Dendritic Nanotechnologies, Inc.Inventors: Donald A. Tomalia, Veera Reddy Pulgam, Douglas R. Swanson, Boahua Huang
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Publication number: 20100086482Abstract: The present invention describes a process for preparing new looped dendrimer and dendron compounds by controlling the molar amount of branch cell reagent monomer that is combined with various cores bearing core-XR functionalities (e.g., primary, or secondary amines, thiol, or epoxy functionalities). These looped, macrocyclic structures are more robust to various conditions, with greater resistance to acid/base hydrolysis. Alternatively, the looped, macrocyclic structure may offer new orientations that would qualify it as a better chelation ligand for metals, and other similar uses.Type: ApplicationFiled: December 28, 2007Publication date: April 8, 2010Applicant: Dendritic Nanotechnologies, Inc.Inventors: Donald A. Tomalia, Douglas R. Swanson, Baohua Huang, Veera Reddy Pulgam
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Publication number: 20090012033Abstract: The present invention concerns core-shell tecto (dendritic polymers) that are associated with biologically active materials (such as nucleic acids for use for RNAi and in transfection). Also included are formulations for their use. The constructs are useful for the delivery of drugs to an animal or plant and may be in vivo, in vitro or ex vivo.Type: ApplicationFiled: March 3, 2007Publication date: January 8, 2009Inventors: Cordell R. DeMattei, Baohua Huang, Lori A. Reyna, Sonke Svenson, Douglas R. Swanson, Donald A. Tomalia, Michael A. Zhuravel, Veera Reddy Pulgam
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Publication number: 20080221300Abstract: This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which maybe used as intermediates to make the Janus dendrimers or to further react with another reactive moiety.Type: ApplicationFiled: March 27, 2006Publication date: September 11, 2008Inventors: Donald A. Tomalia, Veera Reddy Pulgam, Douglas R. Swanson, Baohua Huang
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Patent number: 6635720Abstract: Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendritic polymer molecule having a plurality of terminal functional groups of a first type which are not reactive with each other, and a plurality of shell dendritic polymer molecules having a plurality of terminal functional groups of a second type which are not reactive with each other, but which are reactive with the terminal functional groups of the first type. Each of the shell dendritic polymer molecules is chemically bonded to the core dendritic polymer molecule by a reaction of at least one of the terminal functional groups of the second type with at least one of the terminal functional groups of the first type.Type: GrantFiled: January 24, 2002Date of Patent: October 21, 2003Assignee: Dendritech Inc.Inventors: Donald A. Tomalia, Srinivas Uppuluri, Douglas R. Swanson, Herbert M. Brothers, II
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Patent number: 6599386Abstract: A method of preparing a vehicle panel assembly for attaching the panel to a vehicle is disclosed which provides a “ready-to-install” panel assembly. The panel assembly includes first and second spaced sides, with the bead of heat activated adhesive provided on the second side of the panel. The panel and bead are heated preferably by applying shortwave and longwave infrared radiation, with the shortwave infrared radiation being applied to an adhesive free side of the panel to heat the panel and, thereby, indirectly heat the bead of the heat activated adhesive. The longwave infrared radiation is applied to the adhesive side of the panel to directly heat the bead and thereby activate the adhesive. The ready-to-install adhesive may be applied on or adjacent to a gasket, such as a polyvinyl chloride (PVC) molding, a urethane molding, or the like.Type: GrantFiled: March 13, 2001Date of Patent: July 29, 2003Assignee: Donnelly CorporationInventors: Douglas R. Swanson, David E. Nestell, Niall R. Lynam
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Patent number: 6521083Abstract: A method of and apparatus for activating a ready-to-install heat activated adhesive for attaching a vehicle panel to a vehicle is disclosed which provides a “ready-to-install” panel assembly. The panel assembly includes first and second spaced apart surfaces, with the bead of heat activated adhesive provided on the second surface of the panel. The panel and bead are heated preferably by applying shortwave and longwave infrared radiation, with the shortwave infrared radiation being applied to an adhesive free side of the panel to heat the panel and, thereby, indirectly heat the bead of the heat activated adhesive. For example, where the window panel is such as a laminated windshield or side window or backlite comprising two glass sheets laminated with a polymer inner layer, such as plasticized polyvinyl butyral, or silicone or the like, it is preferable that the heat activation temperature of the adhesive be less than or equal to about 125° C.Type: GrantFiled: October 20, 1999Date of Patent: February 18, 2003Assignee: Donnelly CorporationInventors: Douglas R. Swanson, David E. Nestell, Niall R. Lynam
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Publication number: 20010039991Abstract: A method of preparing a vehicle panel assembly for attaching the panel to a vehicle is disclosed which provides a “ready-to-install” panel assembly. The panel assembly includes first and second spaced sides, with the bead of heat activated adhesive provided on the second side of the panel. The panel and bead are heated preferably by applying shortwave and longwave infrared radiation, with the shortwave infrared radiation being applied to an adhesive free side of the panel to heat the panel and, thereby, indirectly heat the bead of the heat activated adhesive. The longwave infrared radiation is applied to the adhesive side of the panel to directly heat the bead and thereby activate the adhesive. The ready-to-install adhesive may be applied on or adjacent to a gasket, such as a polyvinyl chloride (PVC) molding, a urethane molding, or the like.Type: ApplicationFiled: March 13, 2001Publication date: November 15, 2001Applicant: Donnelly CorporationInventors: Douglas R. Swanson, David E. Nestell, Niall R. Lynam
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Patent number: 6203639Abstract: A method of preparing a vehicle panel assembly for attaching the panel to a vehicle is disclosed which provides a “ready-to-install” panel assembly. The panel assembly includes first and second spaced sides, with the bead of heat activated adhesive provided on the second side of the panel. The panel and bead are heated preferably by applying shortwave and longwave infrared radiation, with the shortwave infrared radiation being applied to an adhesive free side of the panel to heat the panel and, thereby, indirectly heat the bead of the heat activated adhesive. The longwave infrared radiation is applied to the adhesive side of the panel to directly heat the bead and thereby activate the adhesive. The ready-to-install adhesive may be applied on or adjacent to a gasket, such as a polyvinyl chloride (PVC) molding, a urethane molding, or the like.Type: GrantFiled: February 4, 1999Date of Patent: March 20, 2001Assignee: Donnelly CorporationInventors: Douglas R. Swanson, David E. Nestell, Niall R. Lynam
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Patent number: 6054001Abstract: A method of and apparatus for activating a ready-to-install heat activated adhesive for attaching a vehicle panel to a vehicle is disclosed which provides a "ready-to-install" panel assembly. The panel assembly includes first and second spaced apart surfaces, with the bead of heat activated adhesive provided on the second surface of the panel. The panel and bead are heated preferably by applying shortwave and longwave infrared radiation, with the shortwave infrared radiation being applied to an adhesive free side of the panel to heat the panel and, thereby, indirectly heat the bead of the heat activated adhesive. For example, where the window panel is such as a laminated windshield or side window or backlite comprising two glass sheets laminated with a polymer inner layer, such as plasticized polyvinyl butyral, or silicone or the like, it is preferable that the heat activation temperature of the adhesive be less than or equal to about 125.degree. C., more preferably less than or equal to about 115.degree. C.Type: GrantFiled: February 17, 1998Date of Patent: April 25, 2000Assignee: Donnelly CorporationInventors: Douglas R. Swanson, David E. Nestell, Niall R. Lynam
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Patent number: 6020457Abstract: Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound.Type: GrantFiled: September 30, 1997Date of Patent: February 1, 2000Assignee: Dendritech Inc.Inventors: June W. Klimash, Herbert M. Brothers, II, Douglas R. Swanson, Rui Yin, Ralph Spindler, Donald A. Tomalia, Yong Hsu, Roberta C. Cheng
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Patent number: 5919442Abstract: A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.Type: GrantFiled: August 9, 1996Date of Patent: July 6, 1999Assignees: Dendritech, Inc., University of MichiganInventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson, James R. Baker, Jr., Jolanta F. Kukowska-Latallo
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Patent number: 5705573Abstract: A novel process for preparing poly(2-isopropenyl-2-oxazoline or oxazine) and its methyl methacrylate copolymer, which are useful as water borne curing agents, particularly in the non-stick coating industry. The process converts commercially available poly(methyl methacrylate) into poly(2-isopropenyl-2-oxazoline or oxazine) polymers or copolymers with methyl methacrylate, while circumventing the use of the highly toxic monomer, 2-isopropenyl-2-oxazoline or oxazine. The process involves converting a poly(methacrylic ester) to the corresponding poly(.beta.-hydroxy-N-ethyl or propyl methacrylamide) and activating the ring-forming .beta.-hydroxy-N-ethyl or propyl methacrylamide moiety to form an oxazoline or oxazine ring.Type: GrantFiled: September 5, 1996Date of Patent: January 6, 1998Assignee: Michigan Molecular InstituteInventors: Douglas R. Swanson, Donald A. Tomalia
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Patent number: 5631329Abstract: The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.Type: GrantFiled: March 21, 1995Date of Patent: May 20, 1997Assignee: Dendritech, Inc.Inventors: Rui Yin, Donald A. Tomalia, David M. Hedstrand, Douglas R. Swanson