Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.

Abstract: The present invention relates to compositions for the control of pests, in particular insecticidal suspension concentrates and spray solutions made from them, to processes for their preparation, and to the use of such formulations for the sustained control of animal pests (arthropods) on a variety of surfaces. The present invention furthermore relates to the use of certain polymer dispersions in pesticides, in particular to their use for extending the long-term activity of these compositions when they are applied to surfaces. The present invention furthermore relates to the use of the compositions according to the invention for controlling parasites, in particular ectoparasites, in animals.

Abstract: Provided herein are methods and systems for virtual interactive presence.

Abstract: A method for the automatic examination of knowledge system hierarchies is disclosed. A target TMK hierarchy is represented as a plurality of records in a database. A second TMK hierarchy (a “critic”) is constructed of tasks, subtasks, methods, procedures and actions. The critic hierarchy includes actions that retrieve and examine at least one record of the database representing the target hierarchy. The examination of the record provides a result. The result is of the form of a modification of the processing within the critic hierarchy or of the form of a report or a modification of the target hierarchy's elements, namely, tasks, methods, procedures, actions, class structures, or the relationship between the elements.

Abstract: The present invention relates to compositions for the control of pests, in particular insecticidal suspension concentrates and spray solutions made from them, to processes for their preparation, and to the use of such formulations for the sustained control of animal pests (arthropods) on a variety of surfaces. The present invention furthermore relates to the use of certain polymer dispersions in pesticides, in particular to their use for extending the long-term activity of these compositions when they are applied to surfaces. The present invention furthermore relates to the use of the compositions according to the invention for controlling parasites, in particular ectoparasites, in animals.

Abstract: An optical sight includes an optical train having an optical path therethrough, an entrance, and an exit. A reticle is visible through the exit of the optical path. An unpowered reticle illumination source has a first light source that illuminates the reticle responsive to the level of ambient light, and a second light source that illuminates the reticle with an unpowered light source. The reticle illumination source preferably has a light filter positioned so that ambient light entering the ambient-light receiver is incident upon the light filter, whereupon the light filter transmits filtered light, a light-gathering prism that receives the filtered light and has a diffusing surface disposed to illuminate the reticle using the filtered light, and an unpowered light source positioned to emit light through the diffusing surface to be incident upon the reticle. The unpowered light source may be a tritium light source.

Abstract: Provided herein are methods and systems for virtual interactive presence.

Abstract: A method for the automatic examination of knowledge system hierarchies is disclosed. A target TMK hierarchy is represented as a plurality of records in a database. A second TMK hierarchy (a “critic”) is constructed of tasks, subtasks, methods, procedures and actions. The critic hierarchy includes actions that retrieve and examine at least one record of the database representing the target hierarchy. The examination of the record provides a result. The result is of the form of a modification of the processing within the critic hierarchy or of the form of a report or a modification of the target hierarchy's elements, namely, tasks, methods, procedures, actions, class structures, or the relationship between the elements. The report is in a form suitable for printing or displaying on a computer monitor. The modification of the target hierarchy is of the form of writing one or more records to the database representing the target hierarchy.

Abstract: An optical sight includes an optical train having an optical path therethrough, an entrance, and an exit. A reticle is visible through the exit of the optical path. An unpowered reticle illumination source has a first light source that illuminates the reticle responsive to the level of ambient light, and a second light source that illuminates the reticle with an unpowered light source. The reticle illumination source preferably has a scintillation material positioned so that ambient light entering the ambient-light receiver is incident upon the scintillation material, whereupon the scintillation material responsively emits secondary light. A light-gathering prism receives the secondary light and has a diffusing surface disposed to illuminate the reticle using the secondary light. An unpowered light source is positioned to emit light through the diffusing surface to be incident upon the reticle. The unpowered light source may be a tritium light source.

Abstract: A weapon sight has an optical system that causes first radiation to propagate along a path of travel within the sight, and has a reticle generating portion that causes second radiation representing a reticle to propagate along the path of travel with the first radiation. The reticle generating portion includes a reticle illuminating portion that illuminates the reticle, and the reticle illuminating portion includes a light source and a lens portion. Light from the light source passes through the lens portion, and then illuminates the reticle.

Abstract: An optical sight includes an optical train having an optical path therethrough, an entrance, and an exit. A reticle is visible through the exit of the optical path. An unpowered reticle illumination source has a first light source that illuminates the reticle responsive to the level of ambient light, and a second light source that illuminates the reticle with an unpowered light source. The reticle illumination source preferably has a scintillation material positioned so that ambient light entering the ambient-light receiver is incident upon the scintillation material, whereupon the scintillation material responsively emits secondary light. A light-gathering prism receives the secondary light and has a diffusing surface disposed to illuminate the reticle using the secondary light. An unpowered light source is positioned to emit light through the diffusing surface to be incident upon the reticle. The unpowered light source may be a tritium light source.

Abstract: An optical sight includes an optical train having an optical path therethrough, an entrance, and an exit. A reticle is visible through the exit of the optical path. An unpowered reticle illumination source has a first light source that illuminates the reticle responsive to the level of ambient light, and a second light source that illuminates the reticle with an unpowered light source. The reticle illumination source preferably has a light filter positioned so that ambient light entering the ambient-light receiver is incident upon the light filter, whereupon the light filter transmits filtered light, a light-gathering prism that receives the filtered light and has a diffusing surface disposed to illuminate the reticle using the filtered light, and an unpowered light source positioned to emit light through the diffusing surface to be incident upon the reticle. The unpowered light source may be a tritium light source.

Abstract: Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer.

Abstract: A flexible panel having an window aperture with a clear covering and a cooperating pocket behind the window for holding an information containing placard. One embodiment utilizes a magnetic frame for attachment to a surface. Another embodiment uses an angled bracket attached to a stadium seat to tilt the placard toward the viewer in the seat behind.

Abstract: The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

Abstract: The invention provides a variety of reagents for use in the diagnosis and management of cancer, particularly breast cancer. cDNA microarray technology was used to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of cancer and for identification of therapies for cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

Abstract: Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer.

Abstract: The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.

Abstract: The present invention provides methods and reagents relating to establishing and using biomarker:chemical compound correlations. The invention provides correlated biomarker:compound pairs, and further provides methods of using such pairs, for example, in the identification of tumors or tumor cells likely to be responsive or resistant to particular therapy, and/or the identification of chemical compounds likely (or unlikely) to be useful in the treatment of particular tumors.

Abstract: The present invention provides methods and systems for managing call reports. A call report message and information identifying a client matter are received via a wireless network, a distribution list is determined by applying a set of visibility rules, and the call report is created. Access to the call report is based on the distribution list. The visibility rules are rules that encapsulate the various legal and ethical requirements for allowing access to a client matter. The visibility rules may be created using a suitable script language, and be adjusted from time to time.