Patents by Inventor Douglas S. WATSON

Douglas S. WATSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for liposomal formulation of antigens and uses thereof
    Patent number: 10369229
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: August 6, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MOLECULAR EXPRESS, INC.
    Inventors: Gary Fujii, Francis C. Szoka, Douglas S. Watson
  • Chromatography process for purification of insulin and insulin analogs
    Patent number: 10155799
    Abstract: A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 18, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Douglas S. Watson, Allison D. Ortigosa, Michael A. Rauscher, Kathryn M. Story
  • Method for preparing crystalline insulin or insulin analog compositions
    Patent number: 10124040
    Abstract: A method for crystallizing insulin or insulin analogs under alkaline conditions in the presence of zinc, purifying the crystals by filtering through a filter, and drying the crystals captured on the filter to produce crystalline insulin or insulin analog compositions is described. Method has been exemplified with insulin lispro.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: November 13, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Douglas S. Watson, Allison C. Ortigosa, Mark C. Sleevi, Kathryn M. Story
  • METHODS AND COMPOSITIONS FOR LIPOSOMAL FORMULATION OF ANTIGENS AND USES THEREOF
    Publication number: 20180280534
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Application
    Filed: April 2, 2018
    Publication date: October 4, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MOLECULAR EXPRESS, INC.
    Inventors: Gary FUJII, Francis C. SZOKA, Douglas S. WATSON
  • Methods and compositions for liposomal formulation of antigens and uses thereof
    Patent number: 9931419
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: April 3, 2018
    Assignees: MOLECULAR EXPRESS, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Gary Fujii, Francis C. Szoka, Jr., Douglas S. Watson
  • METHOD FOR PREPARING CRYSTALLINE INSULIN OR INSULIN ANALOG COMPOSITIONS
    Publication number: 20170209545
    Abstract: A method for crystallizing insulin or insulin analogs under alkaline conditions in the presence of zinc, purifying the crystals by filtering through a filter, and drying the crystals captured on the filter to produce crystalline insulin or insulin analog compositions is described. Method has been exemplified with insulin lispro.
    Type: Application
    Filed: August 21, 2015
    Publication date: July 27, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Douglas S. Watson, Allison C. Ortigosa, Mark C. Sleevi, Kathryn M. Story
  • CHROMATOGRAPHY PROCESS FOR PURIFICATION OF INSULIN AND INSULIN ANALOGS
    Publication number: 20170174737
    Abstract: A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.
    Type: Application
    Filed: July 16, 2015
    Publication date: June 22, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Douglas S. Watson, Allison D. Ortigosa, Michael A. Rauscher, Kathryn M. Story
  • METHODS AND COMPOSITIONS FOR LIPOSOMAL FORMULATION OF ANTIGENS AND USES THEREOF
    Publication number: 20170157266
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Application
    Filed: June 13, 2016
    Publication date: June 8, 2017
    Inventors: Gary FUJII, Francis C. SZOKA, JR., Douglas S. WATSON
  • Methods and compositions for liposomal formulation of antigens and uses thereof
    Patent number: 9364563
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 14, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MOLECULAR EXPRESS, INC.
    Inventors: Gary Fujii, Francis C. Szoka, Jr., Douglas S. Watson
  • METHODS AND COMPOSITIONS FOR LIPOSOMAL FORMULATION OF ANTIGENS AND USES THEREOF
    Publication number: 20140308341
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Application
    Filed: June 30, 2014
    Publication date: October 16, 2014
    Inventors: Gary FUJII, Francis C. SZOKA, JR., Douglas S. WATSON
  • Methods and compositions for liposomal formulation of antigens and uses thereof
    Patent number: 8765171
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: July 1, 2014
    Assignees: The Regents of the University of California, Molecular Express, Inc.
    Inventors: Gary Fujii, Francis C. Szoka, Jr., Douglas S. Watson
  • METHODS AND COMPOSITIONS FOR LIPOSOMAL FORMULATION OF ANTIGENS AND USES THEREOF
    Publication number: 20100226973
    Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
    Type: Application
    Filed: March 9, 2010
    Publication date: September 9, 2010
    Inventors: Gary FUJII, Francis C. SZOKA, JR., Douglas S. WATSON