Patents by Inventor Douglas S. Werner

Douglas S. Werner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230000993
    Abstract: Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
    Type: Application
    Filed: February 16, 2022
    Publication date: January 5, 2023
    Inventors: Kenneth W. Foreman, Hanh Nho Nguyen, Leslie Odame Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 11497757
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: November 15, 2022
    Assignee: BlinkBio, Inc.
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20220184104
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Application
    Filed: February 24, 2022
    Publication date: June 16, 2022
    Inventors: Hanh Nho Nguyen, Leslie Odame Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 11291731
    Abstract: Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: April 5, 2022
    Assignee: BlinkBio, Inc.
    Inventors: Kenneth W. Foreman, Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20210161921
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Application
    Filed: June 29, 2020
    Publication date: June 3, 2021
    Inventors: Hanh Nho Nguyen, Leslie Odame Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 10716801
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: July 21, 2020
    Assignee: BlinkBio, Inc.
    Inventors: Hanh Nho Nguyen, Leslie Odame Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20190290771
    Abstract: Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
    Type: Application
    Filed: February 6, 2018
    Publication date: September 26, 2019
    Inventors: Kenneth W. Foreman, Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20190183913
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Application
    Filed: July 17, 2018
    Publication date: June 20, 2019
    Inventors: Hanh Nho Nguyen, Leslie Odame Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 10293053
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: May 21, 2019
    Assignee: BlinkBio, Inc.
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20190111142
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Application
    Filed: December 18, 2018
    Publication date: April 18, 2019
    Applicants: BlinkBio, Inc., BlinkBio, Inc.
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 10064880
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: September 4, 2018
    Assignee: BlinkBio, Inc.
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20180200273
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Application
    Filed: March 15, 2018
    Publication date: July 19, 2018
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Patent number: 9931407
    Abstract: Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: April 3, 2018
    Assignee: BlinkBio, Inc.
    Inventors: Kenneth W. Foreman, Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20170202970
    Abstract: Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
    Type: Application
    Filed: April 3, 2017
    Publication date: July 20, 2017
    Inventors: Kenneth W. Foreman, Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Publication number: 20150087043
    Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 26, 2015
    Applicants: Coferon, Inc, Cornell University
    Inventors: Lee Daniel Arnold, Maneesh Pingle, Douglas S. Werner
  • Publication number: 20140243286
    Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
    Type: Application
    Filed: February 28, 2014
    Publication date: August 28, 2014
    Applicant: Coferon, Inc.
    Inventors: Lee Daniel Arnold, Kenneth W. Foreman, Douglas S. Werner
  • Publication number: 20140243321
    Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
    Type: Application
    Filed: February 28, 2014
    Publication date: August 28, 2014
    Applicant: Coferon, Inc.
    Inventors: Lee Daniel Arnold, Kenneth W. Foreman, Douglas S. Werner
  • Publication number: 20140243322
    Abstract: Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins.
    Type: Application
    Filed: February 28, 2014
    Publication date: August 28, 2014
    Applicant: Coferon, Inc.
    Inventors: Lee Daniel Arnold, Kenneth W. Foreman, Douglas S. Werner
  • Patent number: 8796455
    Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: August 5, 2014
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Xin Chen, Heather Coate, Andrew Philip Crew, Han-Qing Dong, Ayako Honda, Mark Joseph Mulvihill, Paula A. R. Tavares, Jing Wang, Douglas S. Werner, Kristen Michelle Mulvihill, Kam W. Siu, Bijoy Panicker, Lee D. Arnold, Meizhong Jin, Brian Volk, Qinghua Weng, James David Beard
  • Patent number: 8735405
    Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: May 27, 2014
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Lee D. Arnold, Cara Cesario, Heather Coate, Andrew P. Crew, Hanqing Dong, Kenneth Foreman, Ayako Honda, Radoslaw Laufer, An-Hu Li, Kristen Michelle Mulvihill, Mark J. Mulvihill, Anthony I. Nigro, Bijoy Panicker, Arno G. Steinig, Yingchuan Sun, Quinghua Weng, Douglas S. Werner, Michael J. Wyle, Tao Zhang