Patents by Inventor Douglas Schein
Douglas Schein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110129908Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaccs, Douglas Schein
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Publication number: 20110129810Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Publication number: 20110059429Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: November 5, 2010Publication date: March 10, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110053256Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: November 5, 2010Publication date: March 3, 2011Applicant: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110039253Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: October 22, 2010Publication date: February 17, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. OWEN, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein, Christopher G. Curtis
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Patent number: 7824848Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: July 11, 2003Date of Patent: November 2, 2010Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20100221696Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: ORGAN RECOVERY SYSTEMS, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 7749693Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. During the period in which the organ is preserved and/or maintained, various drug research and development may be performed on and/or with the organ.Type: GrantFiled: February 2, 2004Date of Patent: July 6, 2010Assignee: Lifeline Scientific, Inc.Inventors: John Brassil, Douglas Schein, Christopher Curtis
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Publication number: 20100151559Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces of the cassette.Type: ApplicationFiled: February 16, 2010Publication date: June 17, 2010Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Jeffrey C. Garland, Douglas Schein, David Walter Wright
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Publication number: 20100112542Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.Type: ApplicationFiled: December 31, 2009Publication date: May 6, 2010Applicant: ORGAN RECOVERY SYSTEMS, INC.Inventors: David Walter Wright, Douglas Schein, John Brassil
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Patent number: 7691622Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces of the cassette.Type: GrantFiled: April 2, 2004Date of Patent: April 6, 2010Assignee: Lifeline Scientific, Inc.Inventors: Jeffrey C. Garland, Douglas Schein, David Walter Wright
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Patent number: 7678563Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.Type: GrantFiled: April 2, 2004Date of Patent: March 16, 2010Assignee: Organ Recovery Systems, Inc.Inventors: David Walter Wright, Douglas Schein, John Brassil
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Publication number: 20040248281Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.Type: ApplicationFiled: April 2, 2004Publication date: December 9, 2004Applicant: ORGAN RECOVERY SYSTEMS, INC.Inventors: David Walter Wright, Douglas Schein, John Brassil
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Publication number: 20040241634Abstract: A method for controlling a pump for delivery of liquid to an organ over a series of fixed-length time intervals f, each interval f comprising a time t1 and a time t2 wherein t1+t2 equals the length of interval f. The method comprises allowing output pressure of the pump to decrease over time t1, increasing output pressure of the pump over time t2, comparing achieved pump output pressure to a predetermined pressure at about the end of interval f, and at least one of (i) adjusting t1 and t2 if necessary so the predetermined pressure is approximated by the output pressure at the end of the next interval f, and (ii) adjusting a rate of change of the output pressure during at least one of t1 and t2 if necessary so the predetermined pressure is approximated by the output pressure at the end of the next interval f.Type: ApplicationFiled: June 2, 2003Publication date: December 2, 2004Applicant: Organ Recovery SystemsInventors: Roger Millis, John Foley, Douglas A. Schein, John M. Brassil
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Publication number: 20040235142Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.Type: ApplicationFiled: April 2, 2004Publication date: November 25, 2004Applicant: ORGAN RECOVERY SYSTEMSInventors: Douglas Schein, Lee William Travis
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Publication number: 20040224298Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. During the period in which the organ is preserved and/or maintained, various drug research and development may be performed on and/or with the organ.Type: ApplicationFiled: February 2, 2004Publication date: November 11, 2004Inventors: John Brassil, Douglas Schein, Christopher G. Curtis
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Publication number: 20040224299Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces of the cassette.Type: ApplicationFiled: April 2, 2004Publication date: November 11, 2004Applicant: ORGAN RECOVERY SYSTEMSInventors: Jeffrey C. Garland, Douglas Schein, David Walter Wright
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Publication number: 20040111104Abstract: A cannula connects an organ with a perfusion system that monitors, treats, sustains and/or restores the viability of the organ and/or that transports and/or stores the organ. At least part of a cannula may be made of a soft elastomer to help avoid damage to the organ. In embodiments, the cannula includes a top portion, a bottom portion, a sealing ring and two compression straps. In embodiments, the cannula includes a top portion and a flexible bottom portion that may be attached to the top portion. In embodiments, part of the cannula is inserted directly into an artery and a suture is used to tie the artery in place. Also, the cannula may include an attachment feature that can be used to connect the cannula to an organ platform or chair. Various features of the cannula may allow a visual check for and venting of air bubbles in the cannula.Type: ApplicationFiled: August 25, 2003Publication date: June 10, 2004Applicant: ORGAN RECOVERY SYSTEMSInventors: Douglas A. Schein, David W. Wright, Raymond Sirianne, Philip D. Palermo, Russell J. Kroll, John M. Brassil
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Patent number: D531319Type: GrantFiled: April 4, 2003Date of Patent: October 31, 2006Assignee: Organ Recovery SystemsInventors: Douglas A. Schein, Lee W. Travis
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Patent number: D531320Type: GrantFiled: April 4, 2003Date of Patent: October 31, 2006Assignee: Organ Recovery SystemsInventors: Jeffrey C. Garland, Douglas A. Schein