Abstract: Disclosed are molecules useful in the treatment or prevention of viral infections in humans and animals and/or the treatment or prevention of the associated symptoms, diseases and/or conditions. The disclosure provides molecules which comprise sugar (carbohydrate/polysaccharide/sialic acid/glycan)-binding protein(s) which are useful in the treatment or prevention of Coronavirus infections and/or diseases, symptoms and/or conditions caused or contributed to by the same.

Abstract: A dual light source lens-free dielectrophoresis (DEP) flow cytometer for massively parallel single cell analysis. Each cells dielectric is inferred from measuring their altitude and subsequently velocity change due to DEP actuation in a microfluidic channel. Dual LED sources facilitate velocity measurement by producing two shadows for each cell passing through the channel. These shadows are detected using a linear optical array detector. Massively parallel analysis is possible as each pixel of the detector can independently analyze the passing cells. The DEP cytometer is composed of simple modular components and has the potential to be scaled to achieve a significantly high throughput label-free single-cell analyzer.

Abstract: A dual light source lens-free dielectrophoresis (DEP) flow cytometer for massively parallel single cell analysis. Each cells dielectric is inferred from measuring their altitude and subsequently velocity change due to DEP actuation in a microfluidic channel. Dual LED sources facilitate velocity measurement by producing two shadows for each cell passing through the channel. These shadows are detected using a linear optical array detector. Massively parallel analysis is possible as each pixel of the detector can independently analyze the passing cells. The DEP cytometer is composed of simple modular components and has the potential to be scaled to achieve a significantly high throughput label-free single-cell analyzer.

Abstract: Embodiments of an improved sensor for dielectrophoretic cytometry are presented. In one embodiment, the sensor includes a plurality of sensor electrodes as well as an actuation electrode. Embodiments of microfluidic systems incorporating such sensor are also described. Additionally, embodiments of methods or performing cytometry analysis are also presented.

Abstract: The present invention provides novel imidazo[1,2-a]pyridine compounds that are useful in therapy of diseases and disorders. The novel compounds inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization.

Abstract: A system and a method for measuring properties and health of structures are disclosed. The system comprises a number of sensors connected to a single antenna. Each sensor has a body that defines an electromagnetic resonator. The electromagnetic resonator produces a response signal in response to an interrogation signal. The body is coupled to the structure to so as to allow the parameters of interest alter the resonance properties of the electromagnetic resonators thereby altering the response signal. The sensor further includes a coupler that is coupled to the body. The coupler transfers the interrogation signal into the electromagnetic resonator and transfers the response signal from the electromagnetic resonator. The system further includes an interrogator that generates and transmits the interrogation signal to the sensor. The interrogator also receives the response signal.

Abstract: The system (10) comprises a sensor (18) 90×90×90×30 mm as an electromagnetic microwave cavity (20) with a coupler (22) with a wire (40) and an antenna (42). Cavity (20) produces a response signal (26) in response to an interrogation signal (24) from interrogator (16). Sensor (18) is coupled to a structure (14) to allow a strain to alter the resonance properties. 3.6 GHz is used with a detection of a 2.5 kHz change. If not temperature via strain is detected a mechanical amplifier is used with cavity (20) for temperature compensation. Continuous or intermittent narrowband signals are used as interrogation signals (24). Used with bridges for structural health monitoring. Also for aircrafts, dams, buildings, vehicles.