Patents by Inventor Douglas W. Phillipson

Douglas W. Phillipson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic gyrase inhibitors
    Patent number: 10858360
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: December 8, 2020
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • TRICYCLIC GYRASE INHIBITORS
    Publication number: 20170369498
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: July 7, 2017
    Publication date: December 28, 2017
    Applicants: Merck Sharp & Dohme Corp., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Tricyclic gyrase inhibitors
    Patent number: 9732083
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: August 15, 2017
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • TRICYCLIC GYRASE INHIBITORS
    Publication number: 20120238751
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: March 14, 2012
    Publication date: September 20, 2012
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Scopularin
    Patent number: 5294725
    Abstract: A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: March 15, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald R. Kirsch, Joseph O'Sullivan, Douglas W. Phillipson
  • 4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof
    Patent number: 5270334
    Abstract: Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: December 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Douglas W. Phillipson, Henner Straub, Peter H. Ermann
  • Chemical derivatives of antibiotics LL-E19020 alpha and beta
    Patent number: 5077277
    Abstract: Derivatives of antibiotics derived from the microorganism Streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta, are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: December 31, 1991
    Assignee: American Cyanamid Company
    Inventors: Douglas W. Phillipson, Guy T. Carter, Donald B. Borders