Abstract: Treatment of SIRS, sepsis, severe sepsis and septic shock in a mammalian subject in which iNOS is present by decreasing the proteolytic cleavage of the iNOS protein using a protease inhibitor is described.

Abstract: A method of effecting a model of sepsis, severe sepsis, or septic shock in a mammalian subject which utilizes the step of introducing particulate or vesicle associated iNOS into the body of the mammalian subject. Prior to or during such introduction, an innate immune system activator may be introduced into the body of the mammalian subject. Other substances may also be introduced into the mammalian subject prior to or during the introduction of the particulate or vesicle associated iNOS in order to observe the physiological consequences on the mammalian subject.

Abstract: A therapeutic agent which removes or neutralizes iNOS in the blood of a mammalian subject. The agent may be in the form of an anti-iNOS monoclonal antibody or an iNOS binding entity.

Abstract: A therapeutic agent which removes or neutralizes iNOS in the blood of a mammalian subject. The agent may be in the form of an anti-iNOS monoclonal antibody or an INOS binding entity.

Abstract: A fire extinguisher system is provided including a wall mount with an open front. The wall mount is adapted to be situated within an opening formed in a recipient surface such that the open front is in coplanar relationship therewith. Next provided is a housing having a closed front face with an aperture formed therein. A fire extinguisher is provided having an actuation assembly adapted to release the fire extinguishing material upon the detection of a temperature above a predetermined amount. The fire extinguisher is situated within the housing with the actuation assembly protruding from the aperture thereof. During use, the housing may be removably situated within the wall mount with the front face of the housing remaining in coplanar relationship with the open front of the wall mount.