Abstract: The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.

Abstract: A single-dose cartridge inhaler comprises a dosing chamber configured to contain dry powder medicament, a transducer and a controller electrically coupled to the transducer. The medicament delivery device is capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose preferably having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%.

Abstract: A intranasal device and method for self-administration of a medicament are provided. The intranasal device includes a body, a catheter, a feedback mechanism, and a delivery system. The body has a chamber configured to store the medicament. The body defines a channel that extends from an interior of the body to an exterior of the body. The catheter is configured to be actuated to extend from the body through the channel and is in fluid communication with the chamber. A distal end of the catheter is configured for entry into a nasal passage of a patient. The feedback mechanism is configured to indicate a position of the distal end of the catheter within the nasal passage. The delivery system is configured to deliver the medicament from the chamber into the nasal passage via the catheter.

Abstract: A dry powder inhaler including a first chamber having an orifice for holding a dry powder and a gas, and a second chamber connected to the first chamber by at least one passageway for receiving an aerosolized form of the dry powder from the first chamber and delivering the aerosolized dry powder to a user. At least one optical sensor monitors aerosolized powder particles passing in the second chamber. A vibrator coupled to the first chamber aerosolizes the dry powder and causes the aerosolized powder to move through the at least one passageway thereby delivering the powder from the first chamber to the second chamber as an aerosolized dry powder. A vibrator control unit controls operation of the vibrator based on the amount of aerosolized powder particles passing in the second chamber and delivered to a user.

Abstract: A dry powder inhaler consisting of a first chamber having an orifice for holding a dry powder and a gas, and a second chamber directly connected to the first chamber by at least one passageway for receiving an aerosolized form of the dry powder from in the first chamber and delivering the aerosolized dry powder to a user. A pressure sensor monitors the pressure in the second chamber. A vibrator coupled to the first chamber aerosolizes the dry powder and cause the aerosolized powder to move through the passageway whereby to deliver the dry powder from the first chamber to the second chamber as an aerosolized dry powder. A vibrator control unit controls operation of the vibrator based on the monitored pressure in the second chamber and a dosing scheme in which the dosing time is determined by the volume of each inhalation.

Abstract: The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.

Abstract: The invention provides an inhalation device using an electrically driven vibratory element for releasing a drug dose into a flow channel, and a controller for activating/deactivating the vibratory element. A sensor arrangement is able to differentiate between inhalation flow and exhalation flow through the flow channel, to assist in forming a model of the breathing pattern of the user. The device can detect reliably inhalation flow patterns from patients of all ages.

Abstract: The invention provides an inhalation device using an electrically driven vibratory element for releasing a drug dose into a flow channel, and a controller for activating/deactivating the vibratory element. A sensor arrangement is able to differentiate between inhalation flow and exhalation flow through the flow channel, to assist in forming a model of the breathing pattern of the user. The device can detect reliably inhalation flow patterns from patients of all ages.

Abstract: An inhaler is disclosed wherein medicament in a flat-bottomed container is aerosolized with a vibrator piezoelectric transducer. The transducer is driven by a signal that excites multiple harmonic frequencies to create a complex pattern of oscillations. A circuit for generating the drive signal to the transducer is also disclosed.

Abstract: An inhaler is disclosed wherein medicament in a flat-bottomed container is aerosolized with a vibrator piezoelectric transducer. The transducer is driven by a signal that excites multiple harmonic frequencies to create a complex pattern of oscillations. A circuit for generating the drive signal to the transducer is also disclosed.