Patents by Inventor Douglas Widman

Douglas Widman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine Compositions
    Publication number: 20260306607
    Abstract: The present disclosure relates to RNAs and other polynucleotides encoding an antigen, which can be used in vaccine compositions. In some examples, the RNA also encodes a chemoattractant, such as chemerin, C-X-C motif chemokine ligand 9 (CX-CL9), C-X-C motif chemokine ligand 10 (CXCL10) or C-X-C motif chemokine ligand 11 (CXCL11). The present disclosure also relates to use of the RNAs and compositions in methods of inducing an immune response in a subject.
    Type: Application
    Filed: May 6, 2024
    Publication date: October 8, 2026
    Applicant: Seqirus Inc.
    Inventors: Douglas Widman, Palaniappan Ramanathan
  • MODIFIED INFLUENZA VIRUSES
    Publication number: 20260071191
    Abstract: The present disclosure relates to the field of modified viruses and viral proteins.
    Type: Application
    Filed: August 16, 2023
    Publication date: March 12, 2026
    Inventors: Charles MCGEE, Gregory EKBERG, Douglas WIDMAN
  • Methods and compositions for dengue virus serotype 4 epitopes
    Patent number: 11241491
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: February 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Matthew Begley, Douglas Widman, Aravinda Desilva, Usha Nivarthi, Boyd Yount, Ellen Young
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20200230224
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 29, 2019
    Publication date: July 23, 2020
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS SEROTYPE 4 EPITOPES
    Publication number: 20200155663
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: May 23, 2018
    Publication date: May 21, 2020
    Inventors: Ralph BARIC, Matthew BEGLEY, Douglas WIDMAN, Aravinda DESILVA, Usha NIVARTHI, Boyd YOUNT, Ellen YOUNG
  • Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
    Patent number: 10398768
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: September 3, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20170333548
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: November 2, 2015
    Publication date: November 23, 2017
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom