Abstract: One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

Abstract: Various ocular fixation devices are disclosed. One ocular fixation device includes first and second rings, where at least one of the rings includes means for fixating ocular tissue of an eye. The means for fixating are arranged to grasp the ocular tissue of the eye and to release the ocular tissue of the eye based on rotation of at least one of the first and second rings. The ocular fixation device may also include one or more structures on which a surgical tool can be mounted on the ocular fixation device at one or more locations. For instance, a dome of the ocular fixation device could include one or more holes that are configured to receive one or more projections from the surgical tool. As another example, a base of the ocular fixation device could include one or more notches configured to receive a projection from the surgical tool.

Abstract: Compounds of formula (IA) or (AB) are kinase inhibitors, especially of CDK2, and/or PDK1 and/or CHK1: wherein Ring A is an optionally substituted aryl, heteroaryl, carbocyclic or heterocyclic radical, Alk represents an optionally substituted clivaient C1-C6 alkylene radical; n is 0 or 1; Q represents a radical of formula -(Alk1)p-(X),(Alk2)s-Z wherein in any compatible combination Z is hydrogen or an optionally substituted carbocyclic or heterocyclic ring, p, r and s are 0 or 1, and Alk1, Alk2, X, are as described in the specification, and R1 represents a radical 3 4 3 (CYC)k-(Alk3)a-(Y)b-(Alk4)d-B wherein k, a, b and d are 0 or 1, and Cyc, Alk3, Alk4 and B are as described in the specification.

Abstract: Compounds of formula (I) or salts, N-oxides, hydrates or solvates thereof are inhibitors of kinase activity, and useful for the treatment of, for example, cancer, psoriasis or restenosis: wherein ring A is an optionally substituted carbocyclic or heterocyclic radical. Alk represents an optionally substituted divalent C1-C6 alkylene radical. n is 0 or 1. Q represents a radical of formula -(Alk1)p (X)r-(Alk2)s-Z wherein in any compatible combination Z is hydrogen or an optionally substituted carbocyclic or heterocyclic ring; Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene radicals which may contain a —O—, —S— or —NRA— link, wherein RA is hydrogen or C1-C6 alkyl; X represents —O—, —S—, —(C?O)—, —(C?S)—, —SO2—, —SO—, —C(?O)O—, —OC(?O)—, —C(?O)NRA—, —NR AC(?O)—, —C(?S)NRA, —NRAC(?S)—, —SO2NRA—, —NRASO2—, —OC(?O)NRA—, —NRAC(?O)O—, or —NRA— wherein RA is hydrogen or C1-C6 alkyl. p, r and s are independently 0 or 1.

Abstract: There is described a convertible table system which has a fixed central portion and leaves along at least two adjacent edges. The leaves fold from an operative position where they are substantially co-planar with the table top to a stored position where they are rotated through 180.degree. to be against or adjacent the bottom of the fixed part of the table. The leaves are retained in the operative position by sliding supports. These supports have pendant portions to be sufficiently robust to withstand the usage to which the table might be put. The pendant portions are able to be retracted out of the paths of the leaves when they are folded to the stored position. The angle of mounting of the sliding supports allows this to occur. The leaves are held in the stored position by a catch which can be magnetic or frictional or other.