Patents by Inventor Douglass M. Bradham, Jr.

Douglass M. Bradham, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Connective tissue growth factor
    Patent number: 7384634
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF and polynucleotides regulating CTGF expression. The invention also provides agents that modulate CTGF and therapeutic methods for using the agents. Also provided are diagnostic methods for using CTGF and assays for identifying agents which affect the expression of CTGF polynucleotide.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 10, 2008
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Methods of diagnosing a pathology characterized by a cell proliferative disorder associated with connective tissue growth factor
    Patent number: 6232064
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5′ and 3′ untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-&bgr; responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: May 15, 2001
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Methods of identifying a composition that alters connective tissue growth factor expression
    Patent number: 6150101
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: November 21, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Methods of accelerating wound healing or of stimulating connective tissue cell growth using connective tissue growth factor
    Patent number: 6149916
    Abstract: Connective Tissue Growth Factor (CTGF), means for producing CTGF, as well as diagnostic and therapeutic methods for using CTGF.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: November 21, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Connective tissue growth factor (CTGF) regulatory nucleic acid sequences
    Patent number: 6069006
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: May 30, 2000
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Assay of connective tissue growth factor for detection of cell proliferative disorders
    Patent number: 5916756
    Abstract: Connective Tissue Growth Factor (CTGF), means for producing CTGF, as well as diagnostic and therapeutic methods for using CTGF.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: June 29, 1999
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Acceleration of wound healing using connective tissue growth factor
    Patent number: 5770209
    Abstract: The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-.beta. responsive element upstream of the polynucleotide encoding CTGF structural gene.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 23, 1998
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.
  • Polynucleotides encoding connective tissue growth factor
    Patent number: 5585270
    Abstract: Polynucleotides encoding connective tissue growth factor (CTGF) are provided. An exemplary polynucleotide of the invention is shown in SEQ ID NO:1. Expression vectors containing CTGF polynucleotide and host cells containing such expression vectors are also included in the invention.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: December 17, 1996
    Assignee: University of South Florida
    Inventors: Gary R. Grotendorst, Douglass M. Bradham, Jr.