Patents by Inventor Douwe J. van Linge

Douwe J. van Linge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions and their use in the prophylaxis and/or treatment of certain diseases
    Patent number: 4296131
    Abstract: The invention relates to a solvent vehicle for therapeutics comprising a dialkyl ester of adipic acid and, optionally, DMSO, which is particularly useful for therapeutic materials having a low solubility or being insoluble in water.The invention further relates to pharmaceutical compositions which are suitable for parenteral administration, especially by intramuscular injection, comprising a therapeutically active material dissolved in said solvent vehicle.Solvent vehicles containing di-n-butyl adipate and DMSO and, if desired, one or more adjuvants, are preferred.Particularly useful are pharmaceutical compositions for the prophylaxis and/or treatment of diseases caused by internal parasites, which can be administered by intramuscular injection. A preferred embodiment of the invention is an injectable composition against distomatosis (liver fluke disease) containing proportionally 12.5 g 4,6'-dichloro-4',6-dinitro-2,2'-methylenediphenol and 30 g of DMSO, completed with di-n-butyl adipate to 100 cm.sup.3.
    Type: Grant
    Filed: August 10, 1979
    Date of Patent: October 20, 1981
    Assignee: ACF Chemiefarma N.V.
    Inventors: Cornelis A. Ladage, Douwe J. Van Linge, Huibert A. Van Riessen
  • Solvent vehicle for the parenteral administration of therapeutics
    Patent number: 4205089
    Abstract: The invention relates to a solvent vehicle for therapeutics comprising a dialkyl ester of adipic acid and, optionally, DMSO, which is particularly useful for therapeutic materials having a low solubility or being insoluble in water. The invention further relates to pharmaceutical compositions which are suitable for parenteral administration, especially by intramuscular injection, comprising a therapeutically active material dissolved in said solvent vehicle. Solvent vehicles containing di-n-butyl adipate and DMSO and, if desired, one or more adjuvants, are preferred. Particularly useful are pharmaceutical compositions for the prophylaxis and/or treatment of diseases caused by internal parasites, which can be administered by intramuscular injection. A preferred embodiment of the invention is an injectable composition against distomatosis (liver fluke disease) containing proportionally 12.5 g 4,6'-dichloro-4',6-dinitro-2,2'-methylene-diphenol and 30 g of DMSO, completed with di-n-butyl adipate to 100 cm.sup.3.
    Type: Grant
    Filed: January 16, 1979
    Date of Patent: May 27, 1980
    Assignee: ACF Chemiefarma N.V.
    Inventors: Cornelis A. Ladage, Douwe J. van Linge, Huibert A. van Riessen