Patents by Inventor Dov Shiffman

Dov Shiffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
    Publication number: 20130030051
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: June 1, 2012
    Publication date: January 31, 2013
    Applicants: UNIVERSITY OF TEXAS BOARD OF REGENTS, CELERA CORPORATION
    Inventors: Dov SHIFFMAN, James J. DEVLIN, Judy Z. LOUIE, Eric BOERWINKLE
  • Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
    Patent number: 8216786
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Celera Corporation
    Inventors: Dov Shiffman, James J. Devlin, Judy Z. Louie, Eric Boerwinkle
  • GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
    Publication number: 20110269735
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 3, 2011
    Applicant: CELERA CORPORATION
    Inventors: Dov SHIFFMAN, James J. DEVLIN, May LUKE, David A. ROSS
  • POLYMORPHISM IN THE APO(A) GENE PREDICT RESPONSIVENESS TO ACETYLSALICYLIC ACID TREATMENT
    Publication number: 20110206667
    Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 25, 2011
    Applicants: The Brigham and Women's Hospital, Inc., Applera Corporation
    Inventors: Paul Ridker, Daniel Chasman, Dov Shiffman
  • Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
    Patent number: 7977052
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: July 12, 2011
    Assignee: Celera Corporation
    Inventors: May M. Luke, James J. Devlin, Dov Shiffman
  • Polymorphism in the Apo(a) gene predict responsiveness to acetylsalicylic acid treatment
    Patent number: 7943317
    Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: May 17, 2011
    Assignees: The Brigham and Women's Hospital, Inc., Applera Corporation
    Inventors: Paul Ridker, Daniel Chasman, Dov Shiffman
  • GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
    Publication number: 20100035983
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: July 9, 2009
    Publication date: February 11, 2010
    Applicants: CELERA CORPORATION, UNIVERSITY OF TEXAS BOARD OF REGENTS
    Inventors: Dov SHIFFMAN, James J. DEVLIN, Judy Z. LOUIE, Eric BOERWINKLE
  • Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
    Publication number: 20090312410
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, specifically MI and including early-onset MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: April 20, 2007
    Publication date: December 17, 2009
    Applicant: APPLERA CORPORATION
    Inventors: Dov Shiffman, James J. Devlin
  • GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY HEART DISEASE, METHODS OF DETECTION AND USES THEREOF
    Publication number: 20090264453
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: April 27, 2009
    Publication date: October 22, 2009
    Applicant: CELERA CORPORATION
    Inventors: Dov SHIFFMAN, Michele CARGILL, James J. DEVLIN
  • POLYMORPHISM IN THE APO(A) GENE PREDICT RESPONSIVENESS TO ACETYLSALICYLIC ACID TREATMENT (RIDKER)
    Publication number: 20090004187
    Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.
    Type: Application
    Filed: May 9, 2008
    Publication date: January 1, 2009
    Inventors: Paul Ridker, Daniel Chasman, Dov Shiffman
  • Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
    Publication number: 20080248476
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: October 23, 2007
    Publication date: October 9, 2008
    Applicant: APPLERA CORPORATION
    Inventors: Michele Cargill, James J. Devlin, Olga Iakoubova, Dov Shiffman
  • Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
    Publication number: 20070042382
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: March 10, 2004
    Publication date: February 22, 2007
    Applicant: APPLERA CORPORATION
    Inventors: Michele Cargill, James Devlin, Olga Iakoubova, Dov Shiffman
  • Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
    Publication number: 20060228715
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: March 7, 2005
    Publication date: October 12, 2006
    Applicant: APPLERA CORPORATION
    Inventors: Dov Shiffman, Michele Cargill, James Devlin
  • Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
    Publication number: 20060223093
    Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
    Type: Application
    Filed: March 13, 2006
    Publication date: October 5, 2006
    Applicant: APPLERA CORPORATION
    Inventors: May Luke, James Devlin, Dov Shiffman, Michele Cargill
  • Genes expressed in treated foam cells
    Publication number: 20030194721
    Abstract: The invention relates to isolated polynucleotides, purified polypeptides, and compositions comprising pluralities of polynucleotides that are differentially expressed when foam cells are treated with oxidized low-density lipoprotein and LPS as associated with atherosclerosis. The invention also presents the use of the polynucleotides as elements on a substrate and provides methods for using the polynucleotides and polypeptides.
    Type: Application
    Filed: September 18, 2002
    Publication date: October 16, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Thomas Mikita, Dov Shiffman, J. Gordon Porter, Matthew R. Kaser
  • Genes expressed in foam cell differentiation
    Publication number: 20030165924
    Abstract: The present invention relates to purified polynucleotides and compositions comprising pluralities of polynucleotides that are differentially expressed during foam cell development and are associated with atherosclerosis. The present invention presents the use of the compositions as elements on a substrate, and provides methods for using the compositions and polynucleotides.
    Type: Application
    Filed: October 4, 2002
    Publication date: September 4, 2003
    Inventors: Dov Shiffman, Roland Somogyi, Richard Lawn, Jeffrey J. Seilhamer, J. Gordon Porter, Thomas Mikita, Julie Tai