Abstract: Methods for treating and/or preventing choroidal neovascularization (CNV) or retinal leakage associated with CNV are disclosed, comprising the use of activated protein C (APC) and/or an APC variant. A disclosed method may be applied in the treatment or prevention of ocular diseases, disorders or conditions that are caused directly by CVN, feature development of CNV as a secondary stage or a complication thereof, and/or feature CNV as a synchronous or asynchronous sequela thereof. An exemplary disease treatable by a disclosed method is neovascular age-related macular degeneration (nAMD).

Abstract: Use of activated protein C (APC) for treatment and prevention of ocular diseases, disorders or conditions associated with retinal leakage and CNV such as age-related macular degeneration, optionally in combined therapy with anti-angiogenesis, anti-inflammatory, immunosuppressive, and anti PDGF agent.

Abstract: A method is provided for implanting, in an eye, apparatus having an electrode array including stimulating electrodes shaped to define distal tips protruding from the array, a plurality of photosensors, and driving circuitry, configured to drive the electrodes to apply currents to the retina. The method includes removing a lens of the eye and a vitreous body of the eye, creating a corneoscleral incision and inserting the apparatus through the corneoscleral incision into a vitreous cavity of the eye. During the inserting, an orientation of the distal tips is maintained pointing towards a cornea of the eye. Subsequently to the inserting, the apparatus is rotated such that the distal tips point towards a macula of the eye. Subsequently to the rotating, the apparatus is positioned epi-retinally, such that the distal tips of the electrodes penetrate the retina. Other applications are also described.