Patents by Inventor Dragos Amarie
Dragos Amarie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10821437Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: August 20, 2018Date of Patent: November 3, 2020Assignee: The Trustees of Indiana UniversityInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
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Publication number: 20190136169Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: December 28, 2018Publication date: May 9, 2019Applicant: Indiana University Research and Technology CorporationInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shirinifard, Dragos Amarie
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Patent number: 10196596Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: GrantFiled: February 22, 2016Date of Patent: February 5, 2019Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: James A. Glazier, Abdelkrim Alileche, Abbas Shirinifard, Dragos Amarie
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Publication number: 20190009273Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: ApplicationFiled: August 20, 2018Publication date: January 10, 2019Inventors: James A. GLAZIER, Stephen C. JACOBSON, Dragos AMARIE
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Patent number: 10052628Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: June 30, 2016Date of Patent: August 21, 2018Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
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Publication number: 20160310945Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: ApplicationFiled: June 30, 2016Publication date: October 27, 2016Inventors: James A. GLAZIER, Stephen C. JACOBSON, Dragos AMARIE
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Patent number: 9440207Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: September 18, 2008Date of Patent: September 13, 2016Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
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Publication number: 20160168523Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: February 22, 2016Publication date: June 16, 2016Inventors: James A. GLAZIER, Abdelkrim ALILECHE, Abbas SHIRINIFARD, Dragos AMARIE
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Patent number: 9267099Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: GrantFiled: March 15, 2011Date of Patent: February 23, 2016Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shrinifard, Dragos Amarie
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Patent number: 8355136Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.Type: GrantFiled: June 13, 2011Date of Patent: January 15, 2013Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Dragos Amarie
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Publication number: 20130004469Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: March 15, 2011Publication date: January 3, 2013Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shrinifard, Dragos Amarie
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Patent number: 8169615Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: May 26, 2011Date of Patent: May 1, 2012Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Dragos Amarie
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Publication number: 20110257494Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.Type: ApplicationFiled: June 13, 2011Publication date: October 20, 2011Inventors: James A. Glazier, Dragos Amarie
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Publication number: 20110228277Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: ApplicationFiled: May 26, 2011Publication date: September 22, 2011Inventors: James A. GLAZIER, Dragos Amarie
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Patent number: 7961330Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: March 31, 2010Date of Patent: June 14, 2011Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Dragos Amarie
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Patent number: 7961329Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multichannel sensor for detecting the presence of several targets with a single microchip sensor is described. A multichannel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: March 31, 2010Date of Patent: June 14, 2011Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Dragos Amarie
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Patent number: 7852482Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: March 31, 2010Date of Patent: December 14, 2010Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Bogdan Dragnea, Dragos Amarie
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Publication number: 20100290309Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: ApplicationFiled: September 18, 2008Publication date: November 18, 2010Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORAInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
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Publication number: 20100188663Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: ApplicationFiled: March 31, 2010Publication date: July 29, 2010Inventors: James A. Glazier, Dragos Amarie
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Publication number: 20100189603Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: ApplicationFiled: March 31, 2010Publication date: July 29, 2010Inventors: James A. Glazier, Bogdan Dragnea, Dragos Amarie