Patents by Inventor Drew Adams

Drew Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods of promoting myelination
    Patent number: 12403104
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: September 2, 2025
    Assignee: Case Western Reserve University
    Inventors: Paul J. Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
    Publication number: 20240400579
    Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of myelin-related disorders.
    Type: Application
    Filed: May 21, 2024
    Publication date: December 5, 2024
    Inventors: William VERNIER, Matthew VOLGRAF, Marie-Gabrielle BRAUN, Georgette Marie CASTANEDO, Paul Anthony GIBBONS, James Guy BREITENBUCHER, Drew ADAMS, Brad LANG
  • Compounds and methods of promoting myelination
    Patent number: 12102644
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of 8,9-unsaturated sterols in the OPCs, the agent comprising a compound having the formula (I): wherein variables Y1, R1 and R2 are as defined herein.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: October 1, 2024
    Assignee: Case Western Reserve University
    Inventors: Drew Adams, Dharmaraja Allimuthu, Zita Hubler
  • Compounds for treating myelin related disorders
    Patent number: 12048678
    Abstract: Disclosed is a pharmaceutical composition comprising a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a myelin related disorder in a subject, the method comprising administering to the subject an effective amount of a compound of Structural Formula (I) or a pharmaceutical composition comprising the compound of Structural Formula (I). The variables of Structural Formula (I) are described herein.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: July 30, 2024
    Assignee: Case Western Reserve University
    Inventors: Drew Adams, Paul J. Tesar, Dharmaraja Allimuthu, Zita Hubler, Fadi J. Najm
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20230000798
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: May 27, 2022
    Publication date: January 5, 2023
    Inventors: Paul J. Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • Compounds and methods of promoting myelination
    Patent number: 11344511
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 31, 2022
    Assignee: Case Western Reserve University
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • COMPOUNDS FOR TREATING MYELIN RELATED DISORDERS
    Publication number: 20210353642
    Abstract: Disclosed is a pharmaceutical composition comprising a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a myelin related disorder in a subject, the method comprising administering to the subject an effective amount of a compound of Structural Formula (I) or a pharmaceutical composition comprising the compound of Structural Formula (I). The variables of Structural Formula (I) are described herein.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 18, 2021
    Inventors: Drew Adams, Paul J. Tesar, Dharmaraja Allimuthu, Zita Hubler, Fadi J. Najm
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20210121481
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of 8,9-unsaturated sterols in the OPCs, the agent comprising a compound having the formula (I): wherein variables Y1, R1 and R2 are as defined herein.
    Type: Application
    Filed: April 17, 2019
    Publication date: April 29, 2021
    Inventors: Drew Adams, Dharmaraja Allimuthu, Zita Hubler
  • Compounds and methods of promoting myelination
    Patent number: 10918610
    Abstract: The invention is a method of treating a subject with primary progressive or secondary progressive multiple sclerosis. The method comprises administering an effect amount of Cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine or a pharmaceutically acceptable salt thereof to the subject.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 16, 2021
    Assignee: Case Western Reserve University
    Inventors: Paul Tesar, Drew Adams, Steven B. Landau
  • Compositions and methods for sensitizing a neoplastic cell to radiation
    Patent number: 10449199
    Abstract: The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: October 22, 2019
    Assignees: THE BROAD INSTITUTE, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC., DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Mohamed Abazeed, Matthew Meyerson, Drew Adams
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20190314300
    Abstract: The invention is a method of treating a subject with primary progressive or secondary progressive multiple sclerosis. The method comprises administering an effect amount of Cis-N-cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)prop-2-enylamine or a pharmaceutically acceptable salt thereof to the subject.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 17, 2019
    Inventors: Paul Tesar, Drew Adams, Steven B. Landau
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20190269670
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: July 27, 2017
    Publication date: September 5, 2019
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20180228743
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: January 25, 2018
    Publication date: August 16, 2018
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu
  • COMPOSITIONS AND METHODS FOR SENSITIZING A NEOPLASTIC CELL TO RADIATION
    Publication number: 20160367561
    Abstract: The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.
    Type: Application
    Filed: August 29, 2016
    Publication date: December 22, 2016
    Applicants: THE BROAD INSTITUTE, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC., DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: MOHAMED ABAZEED, MATTHEW MEYERSON, DREW ADAMS
  • Compositions and methods for sensitizing a neoplastic cell to radiation
    Patent number: 9439909
    Abstract: The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: September 13, 2016
    Assignees: The Broad Institute, Inc., Dana-Farher Cancer Institute, Inc., President and Fellows of Harvard College
    Inventors: Mohamed Abazeed, Matthew Meyerson, Drew Adams
  • Compounds, compositions, and methods for cancer therapy
    Patent number: 9108923
    Abstract: Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: August 18, 2015
    Assignees: Howard Hughes Medical Institute, The Broad Institute, The President and Fellows of Harvard College
    Inventors: Drew Adams, Mingji Dai, Stuart Schreiber, Mahmud Mustaqim Hussain, Zarko Boskovic
  • COMPOSITIONS AND METHODS FOR SENSITIZING A NEOPLASTIC CELL TO RADIATION
    Publication number: 20150057486
    Abstract: The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.
    Type: Application
    Filed: August 22, 2014
    Publication date: February 26, 2015
    Inventors: Mohamed Abazeed, Matthew Meyerson, Drew Adams
  • Compounds, Compositions, and Methods for Cancer Therapy
    Publication number: 20140024639
    Abstract: Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 23, 2014
    Inventors: Drew Adams, Mingji Dai, Stuart Schreiber, Mahmud Mustaqim Hussain, Zarko Boskovic