Abstract: A cell culture platform for modeling metastatic cancer is disclosed. The platform comprises one or more cell culture vessels comprising a plurality of compartments. Each compartment houses a substrate include a decellularized tissue-specific extracellular matrix derived from tissue of a different anatomical region. Each tissue-specific extracellular matrix comprises a homogenous mixture of macromolecule fragments including collagen, elastin, and glycosaminoglycan. A kit for culturing cells in biomimetic environments is also disclosed. The kit comprises a plurality of substrate precursors and at least one reagent. Each substrate precursor comprises a decellularized tissue-specific extracellular matrix derived from tissue of a different anatomical region. The tissue-specific extracellular matrix comprises a homogenous mixture of macromolecule fragments including collagen, elastin, and glycosaminoglycan.

Abstract: A composition for topical administration to an epithelium is disclosed. The composition comprises a deconstructed matrisome including one or more enzymatically fragmented peptides derived from biological tissue. The composition further comprises one or more pharmaceutically acceptable or cosmetically acceptable excipients. The deconstructed matrisome may be fragmented through degradation by one or more enzymes to produce the one or more peptides. The one or more peptides may be configured to retain cell signaling ability, thereby promoting one or more of tissue homeostasis, tissue repair, and tissue regeneration. The composition may be used to treat a tissue such as skin tissue exhibiting scarring, acne, eczema, psoriasis, and other skin conditions.