Patents by Inventor Drew Goodman

Drew Goodman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of nucleic acid polymerization by aromatic compounds
    Patent number: 11970731
    Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 30, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Mark Stamatios Kokoris, John Tabone, Melud Nabavi, Aaron Jacobs, Dylan O'Connell, Drew Goodman, Lacey Merrill, Jagadeeswaran Chandrasekar, Kendall Berg, Samantha Vellucci, Jessica Vellucci
  • DP04 POLYMERASE VARIANTS WITH IMPROVED ACCURACY
    Publication number: 20230313157
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: November 16, 2022
    Publication date: October 5, 2023
    Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
  • TRANSLOCATION CONTROL ELEMENTS, REPORTER CODES, AND FURTHER MEANS FOR TRANSLOCATION CONTROL FOR USE IN NANOPORE SEQUENCING
    Publication number: 20220411458
    Abstract: Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocation control element, and a second reporter code, wherein the ends of the reporter construct are attached to phosphoramidate-nucleoside. Related methods and products are also provided.
    Type: Application
    Filed: November 23, 2021
    Publication date: December 29, 2022
    Inventors: Brent Banasik, Cynthia Cech, Jagadeeswaran Chandrasekar, Drew Goodman, Aaron Jacobs, Mark Stamatios Kokoris, Svetlana Kritzer, Matthew Lopez, Cara Machacek, Lacey Merrill, Melud Nabavi, Dylan O'Connell, John Tabone, Jessica Vellucci
  • DPO4 polymerase variants with improved accuracy
    Patent number: 11530392
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: December 20, 2022
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Kokoris, Marc Prindle, Gregory Scott Thiessen, Alexander Isaac Lehmann, Drew Goodman, Aaron Jacobs, John Chase
  • ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS
    Publication number: 20220112548
    Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 14, 2022
    Inventors: Jagadeeswaran Chandrasekar, Drew Goodman, Aaron Jacobs, Mark Stamatios Kokoris, Lacey Merrill, Melud Nabavi, Dylan O'Connell, John Tabone
  • DPO4 POLYMERASE VARIANTS WITH IMPROVED ACCURACY
    Publication number: 20210163903
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and accurate incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 3, 2021
    Inventors: Mark KOKORIS, Marc PRINDLE, Gregory Scott Thiessen, Alexander Isaac LEHMANN, Drew GOODMAN, Aaron JACOBS, John CHASE
  • ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY MINOR GROOVE BINDING MOIETIES
    Publication number: 20210139966
    Abstract: The invention relates to methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 13, 2021
    Inventors: Mark Stamatios Kokoris, John Tabone, Melud Nabavi, Aaron Jacobs, Dylan O'Connell, Drew Goodman, Lacey Merrill, Jagadeeswaran Chandrasekar
  • ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS
    Publication number: 20210062251
    Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Application
    Filed: December 27, 2018
    Publication date: March 4, 2021
    Inventors: Mark Stamatios Kokoris, John Tabone, Melud Nabavi, Aaron Jacobs, Dylan O'Connell, Drew Goodman, Lacey Merrill, Jagadeeswaran Chandrasekar, Kendall Berg, Samantha Vellucci, Jessica Vellucci