Abstract: A point-of-use method for identifying one or more components of an unknown drug sample includes electrochemically analyzing the unknown drug sample to obtain an electrochemical measurement, identifying the components of the unknown drug sample by inputting the electrochemical measurement into a machine learning model trained to identify the components based on the electrochemical measurement, and outputting a listing of the components.

Abstract: Disclosed are systems, devices and methods for a quantitative aptamer-based viral assay. In some aspects, an aptamer-based viral assay device includes a substrate and a biochemical complex conjugated to the substrate, which comprises an aptamer that is initially bound to an enzyme-tagged complementary strand of nucleotides, the aptamer corresponding to an antigen of a virus (e.g., SARS-CoV-2) that has a higher binding affinity to the aptamer than the complementary strand of nucleotides, wherein, when the device is exposed to a solution containing the virus, the enzyme-tagged strand is released from the aptamer as the aptamer binds the antigen of the virus, such that the released enzyme is capable of converting a substance to an analyte that is measurable by a remote analyte meter to correlate with a parameter of the virus in the solution.

Abstract: In one aspect, an analog-to-digital converter circuit includes a transimpedance amplifier including a feedback capacitor electrically connected between an inverting or a non-inverting input of the transimpedance amplifier and an output of the transimpedance amplifier. The circuit includes an hourglass switch electrically connected on a first side to a first input and a second input, and electrically connected on a second side to the non-inverting input and the inverting input. A fine input current to the transimpedance amplifier is received at the first and second inputs. In a first mode, the hourglass switch electrically connects the first input to the non-inverting input and the second input to the inverting input, and in a second mode, the hourglass switch electrically connects the second input to the non-inverting input and the first input to the inverting input.

Abstract: Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.

Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications.

Abstract: An embodiment of a method includes receiving a subscription request specifying one or more destination sites to receive a video feed and respective times at which to deliver the video feed to each of the one or more destination sites over a terrestrial network, wherein respective delivery times are within a publication time range in which the video feed will be available, and configuring available resources to deliver the requested video feed to the one or more destination sites at the respective times.

Abstract: A low-power wake-up receiver. The receiver includes a transformer/filter resonating at a pre-selected frequency to realize passive RF voltage gain. A pseudo-balun envelope detector is coupled to an output of the transformer filter. A comparator or other quantizer is coupled to an output of the active pseudo-balun envelope detector (ED) for comparing the ED output to a comparison threshold voltage. The pseudo-balun envelop detector can be an active detector. The pseudo-balun detector can also be a passive detector.

Abstract: In one aspect, an analog-to-digital converter circuit includes a transimpedance amplifier including a feedback capacitor electrically connected between an inverting or a non-inverting input of the transimpedance amplifier and an output of the transimpedance amplifier. The circuit includes an hourglass switch electrically connected on a first side to a first input and a second input, and electrically connected on a second side to the non-inverting input and the inverting input. A fine input current to the transimpedance amplifier is received at the first and second inputs. In a first mode, the hourglass switch electrically connects the first input to the non-inverting input and the second input to the inverting input, and in a second mode, the hourglass switch electrically connects the second input to the non-inverting input and the first input to the inverting input.

Abstract: An implantable biosensor may be placed subcutaneously to monitor the concentration of an analyte in a body fluid. The biosensor may include an electrochemical cell and an antenna. The components of the biosensor, including the electrochemical cell and the antenna, may be disposed on a same substrate. The electrochemical cell may include multiple electrodes for performing electrochemical measurements that include a first measurement of the analyte concentration in the body fluid, a second measurement of a background interference present in the body fluid, and a third measurement of a pH level within the body fluid. The antenna may receive, from a transceiver, radio frequency (RF) waves for wirelessly powering the implantable biosensor. The antenna may further transmit, back to the transceiver, a backscatter signal encoding a result of the electrochemical measurements.

Abstract: An embodiment of a method includes receiving a subscription request specifying one or more destination sites to receive a video feed and respective times at which to deliver the video feed to each of the one or more destination sites over a terrestrial network, wherein respective delivery times are within a publication time range in which the video feed will be available, and configuring available resources to deliver the requested video feed to the one or more destination sites at the respective times.

Abstract: A low-power wake-up receiver. The receiver includes a transformer/filter resonating at a pre-selected frequency to realize passive RF voltage gain. A pseudo-balun envelope detector is coupled to an output of the transformer filter. A comparator or other quantizer is coupled to an output of the active pseudo-balun envelope detector (ED) for comparing the ED output to a comparison threshold voltage. The pseudo-balun envelop detector can be an active detector. The pseudo-balun detector can also be a passive detector.

Abstract: An embodiment of a method includes receiving a subscription request specifying one or more destination sites to receive a video feed and respective times at which to deliver the video feed to each of the one or more destination sites over a terrestrial network, wherein respective delivery times are within a publication time range in which the video feed will be available, and configuring available resources to deliver the requested video feed to the one or more destination sites at the respective times.

Abstract: Correlated double sampling (CDS) for magnetoresistive (MR) sensors is provided. Here the MR sensor output is sampled at two closely spaced times. The first sample is MR signal+baseline+noise and is sampled when the modulated magnetic field is non-zero. The second sample is baseline+noise only because it is sampled when the modulated magnetic field is zero. The difference between the first and second samples will have significantly reduced low frequency noise and baseline cancellation. Modulation of the electrical bias provided to the MR sensor can be used to provide a baseline signal for temperature compensation. In a second aspect, we provide MR sensor arrays having input and output multiplexing and demultiplexing for row and column line selection, in combination with a per-sensor switch to prevent noise accumulation and bandwidth reduction from idle MR sensors.

Abstract: Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.

Abstract: Correlated double sampling (CDS) for magnetoresistive (MR) sensors is provided. Here the MR sensor output is sampled at two closely spaced times. The first sample is MR signal+baseline+noise and is sampled when the modulated magnetic field is non-zero. The second sample is baseline+noise only because it is sampled when the modulated magnetic field is zero. The difference between the first and second samples will have significantly reduced low frequency noise and baseline cancellation. Modulation of the electrical bias provided to the MR sensor can be used to provide a baseline signal for temperature compensation. In a second aspect, we provide MR sensor arrays having input and output multiplexing and demultiplexing for row and column line selection, in combination with a per-sensor switch to prevent noise accumulation and bandwidth reduction from idle MR sensors.

Abstract: A technique facilitates formation of a burnished region, e.g. a seal region, via plastic deformation of an internal surface. The technique utilizes a burnishing assembly which may comprise a stem sized for insertion into a tubular region. The stem may be combined with an actuator and a plurality of rolling elements mounted on the actuator. When the actuator is actuated to a radially outward position, the plurality of rolling elements may be moved into engagement with the internal surface until plastic deformation occurs. The stem may then the rotated to force the plurality of rolling elements along the internal surface so as to form a region of plastic deformation. The plastic deformation may be located to form a seal, for example, between adjacent components.

Abstract: Correlated double sampling (CDS) for magnetoresistive (MR) sensors is provided. Here the MR sensor output is sampled at two closely spaced times. The first sample is MR signal+baseline+noise and is sampled when the modulated magnetic field is non-zero. The second sample is baseline+noise only because it is sampled when the modulated magnetic field is zero. The difference between the first and second samples will have significantly reduced low frequency noise and baseline cancellation. Modulation of the electrical bias provided to the MR sensor can be used to provide a baseline signal for temperature compensation. In a second aspect, we provide MR sensor arrays having input and output multiplexing and demultiplexing for row and column line selection, in combination with a per-sensor switch to prevent noise accumulation and bandwidth reduction from idle MR sensors.

Abstract: An embodiment of a method includes receiving a subscription request specifying one or more destination sites to receive a video feed and respective times at which to deliver the video feed to each of the one or more destination sites over a terrestrial network, wherein respective delivery times are within a publication time range in which the video feed will be available, and configuring available resources to deliver the requested video feed to the one or more destination sites at the respective times.

Abstract: An embodiment of a method includes receiving a subscription request specifying one or more destination sites to receive a video feed and respective times at which to deliver the video feed to each of the one or more destination sites over a terrestrial network, wherein respective delivery times are within a publication time range in which the video feed will be available, and configuring available resources to deliver the requested video feed to the one or more destination sites at the respective times.

Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detections using transducer arrays. In one embodiment, a transducer array made up of a plurality of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can have a single molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap suitable for conducting redox cycling reactions. In embodiments, by flowing chamber contents, from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule, in the reaction chamber of the at least one transducer element through the fingerprinting region, the redox cycling reactions can be detected to identify the redox-tagged biomolecules.