Patents by Inventor Dror S. Chorev

Dror S. Chorev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of membrane proteins by mass spectrometry
    Patent number: 11885810
    Abstract: A method of detecting a membrane protein by mass spectrometry comprises: (a) providing a solution comprising a native membrane vesicle having a lipid bilayer to which said membrane protein is attached; (b) sonicating the vesicle in the presence of a mass spectrometry-compatible buffer; (c) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (d) vaporising the sonicated solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the vesicle; (e) ionising the membrane protein; (f) resolving the ionised membrane protein using the mass analyser; and (g) detecting the resolved membrane protein using the detector. Also provided are solutions comprising sonicated vesicles for use in mass spectrometry methods.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: January 30, 2024
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Dror S. Chorev, Carol V. Robinson
  • DETECTION OF MEMBRANE PROTEINS BY MASS SPECTROMETRY
    Publication number: 20210325402
    Abstract: A method of detecting a membrane protein by mass spectrometry comprises: (a) providing a solution comprising a native membrane vesicle having a lipid bilayer to which said membrane protein is attached; (b) sonicating the vesicle in the presence of a mass spectrometry-compatible buffer; (c) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (d) vaporising the sonicated solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the vesicle; (e) ionising the membrane protein; (f) resolving the ionised membrane protein using the mass analyser; and (g) detecting the resolved membrane protein using the detector. Also provided are solutions comprising sonicated vesicles for use in mass spectrometry methods.
    Type: Application
    Filed: August 30, 2019
    Publication date: October 21, 2021
    Inventors: Dror S. Chorev, Carol V. Robinson