Patents by Inventor Drzislav Mismer

Drzislav Mismer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purified ciliary neurotrophic factor
    Patent number: 5780600
    Abstract: A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 14, 1998
    Assignee: Amgen Inc.
    Inventors: Franklin D. Collins, Leu-Fen Lin, Drzislav Mismer, Christine Ko
  • Expression of purified ciliary neurotrophic factor
    Patent number: 5141856
    Abstract: A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract.Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: August 25, 1992
    Assignee: Synergen, Inc.
    Inventors: Franklin D. Collins, Leu-Fen Lin, Drzislav Mismer, Christine Ko