Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

Abstract: A method to perform hiearchical video segmentation includes: defining voxels over a spatio-temporal video; grouping into segments contiguous voxels that display similar characteristics including similar appearance or motion; determining a trajectory-based feature that complements color and optical flow cues, wherein trajectory cues are probabilistically meaningful histograms combinable for use in a graph-based framework; and applying a max-margin module for cue combination that learns a supervised distance metric for region dissimilarity that combines color, flow and trajectory features.

Abstract: Monolithically integrated optical resonators are disclosed. An optical resonator may be a nanopillar optical resonator that is formed directly on a substrate and promotes a helically-propagating cavity mode. The helically-propagating cavity mode may result in significant reflection or, total internal reflection at an interface of the nanopillar optical resonator and the substrate even if refractive indices of the nanopillar optical resonator and the substrate are the same or similar. As a result, strong optical feedback, and thus strong resonance, may be provided in the nanopillar optical resonator.

Abstract: The present invention relates to a wind turbine comprising a nacelle, the nacelle having a substantially longitudinal extension, a height extension and a width extension, comprising a front end, a rear end, a bottom part, a top part and side parts, and being adapted to house a number of wind turbine components, which wind turbine components are supported by an internal support structure, the support structure comprising at least a main foundation which is positioned at the front end of the nacelle, and a rear frame which is connected to the main foundation at one end and extends from the main foundation towards the rear end of the nacelle.

Abstract: A method to perform hiearchical video segmentation includes: defining voxels over a spatio-temporal video; grouping into segments contiguous voxels that display similar characteristics including similar appearance or motion; determining a trajectory-based feature that complements color and optical flow cues, wherein trajectory cues are probabilistically meaningful histograms combinable for use in a graph-based framework; and applying a max-margin module for cue combination that learns a supervised distance metric for region dissimilarity that combines color, flow and trajectory features.

Abstract: Embodiments of a monolithically integrated optical resonator are disclosed. In one embodiment, the optical resonator is a nanopillar optical resonator that is formed directly on a substrate and promotes a helically-propagating cavity mode. The helically-propagating cavity mode results in significant reflection or, in some embodiments, total internal reflection at an interface of the nanopillar optical resonator and the substrate even if refractive indices of the nanopillar optical resonator and the substrate are the same or similar. As a result, strong optical feedback, and thus strong resonance, is provided in the nanopillar optical resonator.

Abstract: The present invention relates to a wind turbine comprising a nacelle, the nacelle having a substantially longitudinal extension, a height extension and a width extension, comprising a front end, a rear end, a bottom part, a top part and side parts, and being adapted to house a number of wind turbine components, which wind turbine components are supported by an internal support structure, the support structure comprising at least a main foundation which is positioned at the front end of the nacelle, and a rear frame which is connected to the main foundation at one end and extends from the main foundation towards the rear end of the nacelle.