Patents by Inventor Duan Ma

Duan Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified TFPI and method of treating coagulation using the same
    Patent number: 8912143
    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: December 16, 2014
    Assignee: Fudan University
    Inventors: Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang
  • Genetically Modified TFPI And Method Of Making The Same
    Publication number: 20120065135
    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
    Type: Application
    Filed: November 16, 2011
    Publication date: March 15, 2012
    Applicant: FUDAN UNIVERSITY
    Inventors: Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang
  • Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
    Patent number: 8088599
    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: January 3, 2012
    Assignee: Fudan University
    Inventors: Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang
  • Genetically Modified TFPI And Method Of Making The Same
    Publication number: 20100204095
    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
    Type: Application
    Filed: March 19, 2009
    Publication date: August 12, 2010
    Inventors: Duan MA, Jingui MU, Jiping WANG, Huijun WANG, Wang LIANG