Abstract: The present disclosure relates to prosthesis systems having trays and liners having an asymmetrical locking mechanism to bias the strength of the liner to resist loading forces and associated methods. The tray has a lateral groove disposed in an inner surface of a lateral circumferential portion of the tray and a medial groove disposed in an inner surface of a medial circumferential portion of the tray. The liner has an upper segment and a lower segment. The liner has a locking portion for lockingly engaging the tray that includes the lower segment. The locking portion has a lateral toe positioned generally diametrically opposite a plurality of resiliently deformable medial fingers defined therein. The liner and the tray are engageable in a lateral-to-medial direction so that the plurality of medial fingers can resiliently deform to engage the medial groove subsequent to engagement of the lateral toe within the lateral groove.

Abstract: The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) lithibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.

Abstract: A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.