Abstract: An improved electroporation probe for performing irreversible and reversible electroporation, and administering medicinal drugs at a target tissue is disclosed. An associated lumen of a trocar of the probe is connected to a source of injectable medicinal drug (such as an immunotherapy agent). A probe holder is operable to seal/unseal perforations associated with the trocar through a slidable tube covering the trocar. A plunger of the probe can be operated to administer desired doses of medicinal fluid through the lumen and associated perforations. In an embodiment, the trocar and an electrically conductive region on the tube are respectively connected to cathode and anode terminals of a DC battery. An electric field of desired strength is produced between trocar and the conductive region by sliding the tube to a corresponding position. The probe can be used perform electroporation and to administer desired dose of medicinal drug at the target tissue.

Abstract: An improved electroporation probe that delivers both electroporation and medicinal solution injection via a single instrument, and which allows altering of the applied electric field based on requirements of the target, is disclosed. A proximal end of a hollow tubular probe is connected to an injector for injecting medications, cells, proteins or biologics in solution into the probe, and which in turn are ejected through unsealed perforations on a perforated portion of the probe towards its distal end. A movable sleeve is slidable over the perforated portion of the probe in order to seal or unseal its perforations. A tapered metallic tip at the distal end of the probe is connected to an anode terminal of a battery, the distal end of the movable sleeve is connected to a cathode terminal of the battery.

Abstract: A virtual environment can use an absolute orientation framework. An absolute orientation framework in a virtual environment can be activated using an omnidirectional locomotion platform. An absolute orientation framework enables a user's avatar to move independently from the current viewpoint or camera position. The user's avatar can move in an absolute manner relative to a virtual environment map.

Abstract: A virtual environment can use an absolute orientation framework. An absolute orientation framework in a virtual environment can be activated using an omnidirectional locomotion platform. An absolute orientation framework enables a user's avatar to move independently from the current viewpoint or camera position. The user's avatar can move in an absolute manner relative to a virtual environment map.

Abstract: A virtual environment can use an absolute orientation framework. An absolute orientation framework in a virtual environment can be activated using an omnidirectional locomotion platform. An absolute orientation framework enables a user's avatar to move independently from the current viewpoint or camera position. The user's avatar can move in an absolute manner relative to a virtual environment map.

Abstract: A virtual environment can use an absolute orientation framework. An absolute orientation framework in a virtual environment can be activated using an omnidirectional locomotion platform. An absolute orientation framework enables a user's avatar to move independently from the current viewpoint or camera position. The user's avatar can move in an absolute manner relative to a virtual environment map.

Abstract: A virtual environment can use an absolute orientation framework. An absolute orientation framework in a virtual environment can be activated using an omnidirectional locomotion platform. An absolute orientation framework enables a user's avatar to move independently from the current viewpoint or camera position. The user's avatar can move in an absolute manner relative to a virtual environment map.